Azathioprine vs cyclophosphamide
Azathioprine showed no clear difference in serious adverse events compared with cyclophosphamide (moderate certainty).
- RR 1.18 [0.45, 3.07]1 study · 144 participantsModerate
Azathioprine showed no clear difference in serious adverse events compared with cyclophosphamide (moderate certainty).
Leflunomide showed no clear difference in serious adverse events* compared with methotrexate (low certainty).
The review found no eligible studies for this question.
Urtoxazumab (3.0 mg/kg) may leads to lower adverse events ‐ serious compared with placebo (low certainty).
Rituximab showed no clear difference in serious adverse events compared with cyclophosphamide (moderate certainty).
Mycophenolate mofetil may leads to higher serious adverse events compared with cyclophosphamide (low certainty).
Calcineurin inhibitor showed no clear difference in adverse events: serious infections compared with IV cyclophosphamide (moderate certainty).
Cyclosporin showed no clear difference in adverse events (weeks 0 to 26): serious infection requiring… compared with mycophenolate mofetil with pulse dexamethasone (low certainty).
Calcineurin inhibitor probably leads to lower adverse events: treatment failure at 6 months (non response, serious… compared with IV cyclophosphamide (moderate certainty).