What do systematic reviews say?

LNG‐IUS vs another combined low‐dose OCP

The review found no eligible studies for this question.

• Progestogens or progestogen‐releasing intrauterine systems for uterine fibroids (other than preoperative medical… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

LNG‐IUS vs oral progestogen (norethisterone acetate)

• Progestogens or progestogen‐releasing intrauterine systems for uterine fibroids (other than preoperative medical… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 45 participants
  Very low

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs levonorgestrel intrauterine system

It is very uncertain whether antifibrinolytics changes adverse events (any) compared with levonorgestrel intrauterine system (very low certainty).

• Antifibrinolytics for heavy menstrual bleeding 2018 · Cochrane Headline outcomes only
  RR 0.83 [0.25, 2.8]
  1 study · 42 participants
  Very low

Postoperative use of LNG‐IUD vs postoperative GnRH‐a

• Levonorgestrel‐releasing intrauterine device (LNG‐IUD) for symptomatic endometriosis following surgery 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 40 participants
  Very low

Postoperative use of LNG‐IUD vs expectant management

• Levonorgestrel‐releasing intrauterine device (LNG‐IUD) for symptomatic endometriosis following surgery 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 55 participants
  Very low

Combined oral contraceptive pill vs levonorgestrel intrauterine system

It is very uncertain whether combined oral contraceptive pill changes adverse effects ‐ Any adverse events compared with levonorgestrel‐releasing intrauterine system (very low certainty).

• Combined hormonal contraceptives for heavy menstrual bleeding 2019 · Cochrane Headline outcomes only
  OR 1.5 [0.22, 10.14]
  1 study · 39 participants
  Very low