Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

93 questions · 93 findings · 48 reviews

No studies found 24 · 25.8%GRADE not reported 12 · 12.9%Very low 31 · 33.3%Low 18 · 19.4%Moderate 5 · 5.4%High 3 · 3.2%

Endoscopic surgery vs open surgery

Adverse events (infection, dysaesthesia) · patients with trigger finger

It is very uncertain whether endoscopic surgery changes adverse events (infection, dysaesthesia) compared with open surgery (very low certainty).

1 finding from 1 review

Standard polyurethane plus tissue adhesive vs standard polyurethane

Adverse events assessed during catheter dwell and on product removal · people with arterial catheter dressing and securement

It is very uncertain whether standard polyurethane plus tissue adhesive changes adverse events assessed during catheter dwell and on product removal compared with standard polyurethane (very low certainty).

1 finding from 1 review

Acetazolamide vs placebo

Adverse events: Paresthesias‐ Follow‐ up: From arrival to 24 hours later · participants at risk of high altitude illness

Acetazolamide may leads to higher adverse events: Paresthesias‐ Follow‐ up: From arrival to 24 hours… compared with placebo (low certainty).

1 finding from 1 review

RISPERIDONE DEPOT vs ARIPIPRAZOLE

Adverse events: General ‐ serious Unclear how these events were reported · patients with schizophrenia

It is very uncertain whether RISPERIDONE DEPOT changes adverse events: General ‐ serious Unclear how these events were… compared with ORAL ARIPIPRAZOLE (very low certainty).

1 finding from 1 review

Locking plate vs 2 mm non-locking titanium plates

Post-operative adverse events and complications (paraesthesia, swelling, segmental mobility) · Adults (16 to 68 years) with mandibular fractures excluding condylar involvement
1 finding from 1 review
  • Agarwal 2011: paraesthesia in one participant in the non-locking plate group (resolved by 3 months), none in the locking group; infection rates similar at 6 weeks and 3 months; post-operative swelling in 20% of both…
    1 study
    GRADE not reported

Non‐invasive brain stimulation and pharmacological intervention (combination) vs a pharmacological intervention and sham stimulation or usual care (single)

Adverse events: all ‐ other events ‐ not listed above (e.g. dysuria, neck pain, eye discomfort) (secondary outcome) · people with depression after stroke

It is very uncertain whether pharmacological intervention and non‐invasive brain stimulation… changes adverse events: all ‐ other events ‐ not listed above (e.g.… compared with a pharmacological intervention and sham stimulation or usual care… (very low certainty).

1 finding from 1 review

Percutaneous surgery vs steroid injection

Adverse events (infection, partial loss of movement, tendon or −0 injury, dysaesthesia, and skin atrophy or hypopigmentation) · patients with trigger finger

It is very uncertain whether percutaneous surgery changes adverse events (infection, partial loss of movement, tendon or −0… compared with steroid injection (very low certainty).

1 finding from 1 review

Combination of manual therapy and exercise following joint distension vs sham ultrasound following joint distension

Adverse events · patients with adhesive capsulitis (frozen shoulder)

Combination of manual therapy and exercise following joint distension leads to lower adverse events compared with sham ultrasound following joint distension (high certainty).

1 finding from 1 review