What do systematic reviews say?

Ozone applied to the carious lesion (10 or 40 seconds), with a fluoride reductant and oral hygiene/preventive advice vs No ozone, with a fluoride reductant and oral hygiene/preventive advice (as in the intervention group)

• Ozone therapy for the treatment of dental caries 2004 · Cochrane All outcomes

  To 6 months
  Baysan 2003 stated that no adverse events were reported to 6 months; no information was provided by Abu-Naba'a 2003 or Abu-Naba'a 2003pilot.
  1 study
  GRADE not reported

Silver diamine fluoride (SDF) vs Not applicable (single-arm safety outcome)

No serious adverse events (e.g., allergic reactions or toxicity) were reported for SDF across the reviews (ungraded).

• Silver diamine fluoride for managing carious lesions: an umbrella review. 2019 All outcomes
  No serious adverse events, such as allergic reactions or toxicity, were reported. A metallic taste or burning sensation was not reported in any of the studies.
  Studies not reported
  GRADE not reported

Silver diamine fluoride (SDF) vs Not applicable (single-arm safety outcome)

Black staining of arrested lesions was the main adverse event of SDF (reported by seven reviews); it was generally acceptable to patients (ungraded).

• Silver diamine fluoride for managing carious lesions: an umbrella review. 2019 All outcomes
  Eight systematic reviews reported adverse events; seven reported black staining of arrested carious lesions. Older adults rarely complained; discoloration was acceptable in children, concerning 7% of participants in…
  Studies not reported
  GRADE not reported