What do systematic reviews say?

Prednisone vs placebo

• Treatment for postpolio syndrome 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 17 participants
  GRADE not reported

Prednisone plus azathioprine vs prednisone

• Interventions for bullous pemphigoid 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Very low

Nicotinamide plus tetracycline vs prednisone

• Interventions for bullous pemphigoid 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Very low

Oral cyclophosphamide vs prednisone or placebo

Oral cyclophosphamide showed no clear difference in adverse events: death (all causes) compared with prednisone or placebo (low certainty).

• Interventions for idiopathic steroid‐resistant nephrotic syndrome in children 2019 · Cochrane Headline outcomes only
  RR 1.07 [0.19, 5.95]
  1 study · 60 participants
  Low

Oral cyclophosphamide vs prednisone or placebo

It is very uncertain whether oral cyclophosphamide changes adverse events: hypertension with seizures compared with prednisone or placebo (very low certainty).

• Interventions for idiopathic steroid‐resistant nephrotic syndrome in children 2019 · Cochrane Headline outcomes only
  RR 0.71 [0.05, 10.89]
  1 study · 60 participants
  Very low

Swallowed fluticasone vs prednisone

It is very uncertain whether swallowed fluticasone changes withdrawals due to adverse events at 4 weeks compared with oral prednisone (very low certainty).

• Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
  RR 0.5 [0.16, 1.53]
  1 study · 80 participants
  Very low

Clobetasol propionate cream vs prednisone

Clobetasol propionate cream may leads to lower adverse events: severe complications at day 21 compared with oral prednisone (low certainty).

• Interventions for bullous pemphigoid 2023 · Cochrane Headline outcomes only
  RR 0.65 [0.5, 0.86]
  1 study · 341 participants
  Low