Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

56 questions · 64 findings · 16 reviews · Infectious Diseases

No studies found 4 · 6.3%GRADE not reported 19 · 29.7%Very low 12 · 18.8%Low 14 · 21.9%Moderate 8 · 12.5%High 7 · 10.9%

Fluoroquinolone substitution for ethambutol in a standard six month regimen vs standard regimen

Serious adverse events · Patients with presumed drug‐sensitive TB

It is very uncertain whether fluoroquinolone substitution for ethambutol in a standard six month… changes serious adverse events compared with standard regimen (very low certainty).

1 finding from 1 review

Fluoroquinolone substitution for isoniazid in a standard six month regimen vs standard regimen

Serious adverse events · Patients with presumed drug‐sensitive TB

Fluoroquinolone substitution for isoniazid in a standard six month… showed no clear difference in serious adverse events compared with standard regimen (low certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events · adults with P vivax malaria

It is very uncertain whether the intervention changes serious adverse events (very low certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events · adults and children with P vivax malaria

It is very uncertain whether the intervention changes serious adverse events (very low certainty).

1 finding from 1 review