Findings

What do systematic reviews say?

198 questions · 199 findings · 60 reviews · Gut

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No studies found 34 · 17.1%GRADE not reported 8 · 4%Very low 44 · 22.1%Low 72 · 36.2%Moderate 31 · 15.6%High 10 · 5%

Physical activity advice plus placebo vs no physical activity advice plus placebo

Adverse events: · participants with quiescent IBD

1 finding from 1 review

Interventions for fatigue in inflammatory bowel disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 27 participants
Very low

Physical activity advice plus placebo vs no physical activity advice plus placebo

Serious adverse events ‐ not reported · participants with quiescent IBD

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for fatigue in inflammatory bowel disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Physical activity advice plus placebo vs no physical activity advice plus placebo

Withdrawals due to adverse events ‐ not reported · participants with quiescent IBD

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for fatigue in inflammatory bowel disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Physical activity advice plus placebo vs no physical activity advice plus omega 3

Adverse events: · participants with quiescent IBD

1 finding from 1 review

Interventions for fatigue in inflammatory bowel disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 29 participants
Very low

Physical activity advice plus placebo vs no physical activity advice plus omega 3

Serious adverse events ‐ not reported · participants with quiescent IBD

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for fatigue in inflammatory bowel disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Physical activity advice plus placebo vs no physical activity advice plus omega 3

Withdrawals due to adverse events ‐ not reported · participants with quiescent IBD

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for fatigue in inflammatory bowel disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral 5‐ASA vs placebo

Adverse events · Patients with active mild to moderate ulcerative colitis

Oral 5‐ASA showed no clear difference in adverse events compared with placebo (high certainty).

1 finding from 1 review

Oral 5‐aminosalicylic acid for induction of remission in ulcerative colitis 2020 · Cochrane Headline outcomes only
RR 0.95 [0.85, 1.07]
8 studies · 1218 participants
High

Oral 5‐aminosalicylic acid vs placebo

Adverse events · Patients with quiescent ulcerative colitis

Oral 5‐aminosalicylic acid showed no clear difference in adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Oral 5‐aminosalicylic acid for maintenance of remission in ulcerative colitis 2020 · Cochrane Headline outcomes only
RR 0.93 [0.73, 1.18]
5 studies · 1132 participants
Moderate

Adalimumab vs placebo

Adverse events · Participants with Crohn's disease in remission

Adalimumab showed no clear difference in adverse events compared with placebo (high certainty).

1 finding from 1 review

Adalimumab for maintenance of remission in Crohn's disease 2020 · Cochrane Headline outcomes only
RR 1.01 [0.94, 1.09]
4 studies · 1012 participants
High

Summary of findings table ‐ Rifaximin vs placebo

Adverse events · Patients with acute pouchitis

It is very uncertain whether rifaximin changes adverse events compared with placebo (very low certainty).

1 finding from 1 review

Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis 2019 · Cochrane Headline outcomes only
RR 1.5 [0.72, 3.14]
1 study · 18 participants
Very low

Lactobacillus GG vs placebo

Adverse events · Patients with acute pouchitis

The review found no eligible studies for this question.

1 finding from 1 review

Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Bismuth enema vs placebo

Adverse events · Patients with chronic pouchitis

It is very uncertain whether bismuth enema changes adverse events compared with placebo (very low certainty).

1 finding from 1 review

Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis 2019 · Cochrane Headline outcomes only
RR 0.71 [0.27, 1.88]
1 study · 40 participants
Very low

De Simone Formulation vs placebo

Adverse events · Patients with chronic pouchitis or ileal pouch‐anal anastomosis

De Simone Formulation showed no clear difference in adverse events compared with placebo (low certainty).

1 finding from 1 review

Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis 2019 · Cochrane Headline outcomes only
RR 2.43 [0.11, 55.89]
2 studies · 76 participants
Low

Bifidobacterium longum vs placebo

Adverse events · Patients with ileal pouch‐anal anastomosis

The review found no eligible studies for this question.

1 finding from 1 review

Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Allopurinol vs placebo

Adverse events · Patients with ileal pouch‐anal anastomosis

The review found no eligible studies for this question.

1 finding from 1 review

Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Tinidazole vs placebo

Adverse events · Patients with ileal pouch‐anal anastomosis

The review found no eligible studies for this question.

1 finding from 1 review

Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Adalimumab vs placebo

Adverse events · Patients with ileal pouch‐anal anastomosis

The review found no eligible studies for this question.

1 finding from 1 review

Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Clostridium probiotic vs placebo

Adverse events · Patients with ileal pouch‐anal anastomosis

The review found no eligible studies for this question.

1 finding from 1 review

Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

5‐ASA vs placebo

Adverse events · people with surgically‐induced remission in Crohn's disease

5‐ASAs showed no clear difference in adverse events compared with placebo (low certainty).

1 finding from 1 review

Oral 5‐aminosalicylic acid for maintenance of surgically‐induced remission in Crohn's disease 2019 · Cochrane Headline outcomes only
RR 1.07 [0.6, 1.91]
4 studies · 466 participants
Low

Sulphasalazine vs placebo

Adverse events · people with surgically‐induced remission in Crohn's disease

The review found no eligible studies for this question.

1 finding from 1 review

Oral 5‐aminosalicylic acid for maintenance of surgically‐induced remission in Crohn's disease 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found