Findings

What do systematic reviews say?

2 questions · 4 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 3 · 75%Very low 0 · 0%Low 1 · 25%Moderate 0 · 0%High 0 · 0%

Intraglandular botulinum neurotoxin (BoNT) injection vs placebo injection

Adverse events (participants with >=1 adverse event) · Adults with Parkinson's disease and sialorrhea (drooling)

Type A botulinum toxin showed a borderline, non-significant increase in adverse events versus placebo (RD 0.10, 95% CI 0.00 to 0.21; ungraded subgroup).

3 findings from 1 review

The effectiveness and safety of botulinum toxin injections for the treatment of sialorrhea with Parkinson's disease: a… 2023 All outcomes
Approximately 1 month post-injection (one study ~1 week) · Movement-disorder / neurology outpatient care (trials from Italy, USA, and Estonia) · BoNT type A
RD 0.10 [0.00, 0.21]
5 studies · 117 participants
GRADE not reported
The effectiveness and safety of botulinum toxin injections for the treatment of sialorrhea with Parkinson's disease: a… 2023 All outcomes
Approximately 1 month post-injection (one study ~1 week) · Movement-disorder / neurology outpatient care (trials from Italy, USA, and Estonia)
RD 0.15 [0.05, 0.24]
10 studies · 249 participants
Low
The effectiveness and safety of botulinum toxin injections for the treatment of sialorrhea with Parkinson's disease: a… 2023 All outcomes
Approximately 1 month post-injection (one study ~1 week) · Movement-disorder / neurology outpatient care (trials from Italy, USA, and Estonia) · BoNT type B
RD 0.18 [0.04, 0.33]
5 studies · 132 participants
GRADE not reported

Silver diamine fluoride (SDF) vs Other methods (pooled: ART/glass ionomer cement, nano-silver fluoride, sodium fluoride varnish, placebo)

Adverse effects (tooth staining and other side effects) · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition)

SDF commonly causes black staining of arrested lesions; only mild, transient adverse events were reported, with no major adverse events (ungraded).

1 finding from 1 review

The role of silver diamine fluoride as dental caries preventive and arresting agent: a systematic review and… 2024 All outcomes
up to 30 months · Children/adults with dental caries; multiple countries; community/clinic care setting not clearly specified
Black staining of arrested lesions reported in most studies; 4 studies reported mild transient events (gingival blenching/pain; diarrhea/stomachache; burning, bad taste, pain, mouth injury, dissatisfaction with…
Studies not reported
GRADE not reported