Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

36 questions · 36 findings · 9 reviews

No studies found 16 · 44.4%GRADE not reported 1 · 2.8%Very low 7 · 19.4%Low 9 · 25%Moderate 2 · 5.6%High 1 · 2.8%

Human recombinant activated protein C vs placebo

Serious adverse events (adult and paediatric patients) · patients with severe sepsis or septic shock

Human recombinant activated protein C showed no clear difference in serious adverse events (adult and paediatric patients) compared with placebo (moderate certainty).

1 finding from 1 review

Band ligation vs no intervention or a sham procedure

Serious adverse events Idiopathic thrombocytopaenic purpura · children with portal hypertension and large oesophageal varices, without previous gastrointestinal bleeding or beta‐blocker treatment

It is very uncertain whether band ligation changes serious adverse events Idiopathic thrombocytopaenic purpura compared with sham or no intervention (very low certainty).

1 finding from 1 review