Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

50 questions · 50 findings · 21 reviews · Headline outcomes only

No studies found 7 · 14%GRADE not reported 3 · 6%Very low 18 · 36%Low 15 · 30%Moderate 3 · 6%High 4 · 8%

Ranolazine (monotherapy) vs placebo

Adverse events incidence · patients with stable angina pectoris

It is very uncertain whether ranolazine (monotherapy) changes adverse events incidence compared with placebo (very low certainty).

1 finding from 1 review

Summary of findings: pioglitazone monotherapy vs no intervention

Serious adverse events (N) · people at increased risk for developing type 2 diabetes

Summary of findings: pioglitazone monotherapy showed no clear difference in serious adverse events (N) compared with no intervention (low certainty).

1 finding from 1 review

Summary of findings table ‐ Platinum‐resistant recurrent EOC: PARPi monotherapy vs chemotherapy alone

Adverse events (grade ≥ 3) · recurrent platinum‐resistant EOC

It is very uncertain whether summary of findings table ‐ Platinum‐resistant recurrent EOC: PARPi… changes any severe adverse events (grade 3 or higher) (G3+ SevAE) compared with chemotherapy (very low certainty).

1 finding from 1 review