Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

6 questions · 6 findings · 2 reviews · Tobacco Addiction

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 4 · 66.7%Low 2 · 33.3%Moderate 0 · 0%High 0 · 0%

Heated tobacco use vs cigarette smoking

Serious adverse events – measured by self‐report and medical records · people who smoke

It is very uncertain whether heated tobacco use changes serious adverse events – measured by self‐report and medical records compared with cigarette smoking (very low certainty).

1 finding from 1 review

Nicotine EC vs non‐nicotine EC

Serious adverse events at 1 week to 1 year Assessed via self‐report and medical records · People who smoke cigarettes

Nicotine EC showed no clear difference in serious adverse events at 1 week to 1 year Assessed via self‐report… compared with non‐nicotine EC (low certainty).

1 finding from 1 review

Nicotine EC vs NRT

Serious adverse events at 4 weeks to 1 year Assessed via self‐report and medical records · people who smoke

Nicotine EC showed no clear difference in serious adverse events at 4 weeks to 1 year Assessed via self‐report… compared with NRT (low certainty).

1 finding from 1 review

Nicotine EC vs behavioural support only/no support

Serious adverse events – measured by self‐report and medical records · people who smoke

It is very uncertain whether nicotine EC changes serious adverse events at 4 weeks to 8 months Assessed via… compared with behavioural support only/no support (very low certainty).

1 finding from 1 review