Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

8 questions · 8 findings · 3 reviews · Pain, Palliative and Supportive Care

No studies found 5 · 62.5%GRADE not reported 0 · 0%Very low 1 · 12.5%Low 2 · 25%Moderate 0 · 0%High 0 · 0%

Naloxone + oxycodone prolonged release tablets vs oxycodone

Adverse events · people with cancer irrespective of whether they were receiving palliative care opioid‐induced bowel dysfunction

Naloxone + oxycodone prolonged release tablets showed no clear difference in adverse events compared with oxycodone prolonged‐released tablets (low certainty).

1 finding from 1 review

Naloxone + oxycodone prolonged release tablets vs oxycodone

Serious adverse eventsg · people with cancer irrespective of whether they were receiving palliative care opioid‐induced bowel dysfunction

It is very uncertain whether naloxone + oxycodone prolonged release tablets changes serious adverse eventsg compared with oxycodone prolonged‐released tablets (very low certainty).

1 finding from 1 review

Topical clonidine (TC) vs placebo

Withdrawals due to adverse events · adults with painful diabetic neuropathy

Topical clonidine (TC) showed no clear difference in withdrawals due to adverse events during longest compared with placebo (low certainty).

1 finding from 1 review

Ibuprofen vs paracetamol

Serious adverse events, defined as any medical event at any dose that results in death, is life‐threatening, requires hospitalisation (or prolongation of existing hospitalisation) or results in permanent damage or disability (FDA 2016) · children with acute postoperative pain

The review found no eligible studies for this question.

1 finding from 1 review

Ibuprofen vs morphine

Serious adverse events, defined as any medical event at any dose that results in death, is life‐threatening, requires hospitalisation (or prolongation of existing hospitalisation) or results in permanent damage or disability (FDA 2016) · children with acute postoperative pain

The review found no eligible studies for this question.

1 finding from 1 review

Ibuprofen vs ketorolac

Serious adverse events, defined as any medical event at any dose that results in death, is life‐threatening, requires hospitalisation (or prolongation of existing hospitalisation) or results in permanent damage or disability (FDA 2016) · children with acute postoperative pain

The review found no eligible studies for this question.

1 finding from 1 review

Ibuprofen vs placebo

Serious adverse events, defined as any medical event at any dose that results in death, is life‐threatening, requires hospitalisation (or prolongation of existing hospitalisation) or results in permanent damage or disability (FDA 2016) · children with acute postoperative pain

The review found no eligible studies for this question.

1 finding from 1 review