Probiotics and osmotic laxative vs osmotic laxative
Serious adverse events · children with chronic constipation without a physical explanation
1 finding from 1 review
- no estimate extracted4 studies · 308 participantsGRADE not reported
Findings
What do systematic reviews say?
6 questions · 6 findings · 2 reviews · Gut
No studies found 0 · 0%GRADE not reported 1 · 16.7%Very low 2 · 33.3%Low 2 · 33.3%Moderate 1 · 16.7%High 0 · 0%
Probiotics and osmotic laxative vs osmotic laxative
Withdrawals due to adverse events · children with chronic constipation without a physical explanation
It is very uncertain whether probiotics and osmotic laxative changes withdrawal due to adverse events compared with osmotic laxative (very low certainty).
1 finding from 1 review
- RR 2.86 [0.12, 68.35]3 studies · 268 participantsVery low
High dose PEG vs low dose PEG
Adverse events · patients aged 0 to 18 years with a diagnosis of functional constipation
It is very uncertain whether high dose PEG changes adverse events compared with low dose PEG (very low certainty).
1 finding from 1 review
- Osmotic and stimulant laxatives for the management of childhood constipation 2016 · Cochrane Headline outcomes onlyRR 1 [0.33, 5.88]1 study · 90 participantsVery low
PEG vs lactulose
Adverse events · patients aged 0 to 18 years with a diagnosis of functional constipation
PEG showed no clear difference in adverse events compared with lactulose (moderate certainty).
1 finding from 1 review
- Osmotic and stimulant laxatives for the management of childhood constipation 2016 · Cochrane Headline outcomes onlyRR 0.8 [0.68, 1.11]3 studies · 242 participantsModerate
PEG vs placebo
Serious adverse events · patients aged 0 to 18 years with a diagnosis of functional constipation
PEG showed no clear difference in serious adverse events compared with placebo (low certainty).
1 finding from 1 review
- Osmotic and stimulant laxatives for the management of childhood constipation 2016 · Cochrane Headline outcomes onlyRR 0 [0.02, 1.51]2 studies · 101 participantsLow
PEG vs lactulose
Serious adverse events · patients aged 0 to 18 years with a diagnosis of functional constipation
PEG showed no clear difference in serious adverse events compared with lactulose (low certainty).
1 finding from 1 review
- Osmotic and stimulant laxatives for the management of childhood constipation 2016 · Cochrane Headline outcomes onlyRR 2 [0.37, 15.96]2 studies · 145 participantsLow