What do systematic reviews say?

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs placebo

• Interventions for preventing oral mucositis in patients with cancer receiving treatment: cytokines and growth factors 2017 · Cochrane All outcomes
  Adverse events attributed to KGF were typically oral-related or skin-related; mostly mild to moderate with very few serious events; reporting poor and inconsistent, not appropriate to meta-analyse (SoF comments cell,…
  16 studies
  GRADE not reported

Perioperative infraorbital nerve block vs Intravenous analgesia

• Infraorbital nerve block for postoperative pain following cleft lip repair in children 2016 · Cochrane All outcomes
  2 out of 3 studies reported this outcome. Both studies reported no difference between groups (Rajamani 2007 and Simion 2008: no adverse events attributable to either technique; Delgado 2005 did not report).
  2 studies
  GRADE not reported

Oral paracetamol vs placebo

Paracetamol (single oral dose, any dose or formulation; subgroups up… showed no clear difference in patients with one or more adverse events compared with placebo; GRADE not reported.

• Paracetamol for pain relief after surgical removal of lower wisdom teeth 2007 · Cochrane All outcomes

  up to 7 days
  RR 1.19 [0.90, 1.57]
  17 studies · 1645 participants
  GRADE not reported