Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

12 questions · 12 findings · 5 reviews · Neuromuscular

No studies found 0 · 0%GRADE not reported 3 · 25%Very low 4 · 33.3%Low 1 · 8.3%Moderate 4 · 33.3%High 0 · 0%

Brain‐derived neurotrophic factor vs placebo

Participants with 1 or more serious adverse events · patients with Guillain‐Barré syndrome

It is very uncertain whether brain‐derived neurotrophic factor changes participants with 1 or more serious adverse events compared with placebo (very low certainty).

1 finding from 1 review

Cerebrospinal fluid filtration vs plasma exchange

Participants with 1 or more serious adverse events · patients with Guillain‐Barré syndrome

It is very uncertain whether cerebrospinal fluid filtration changes participants with 1 or more serious adverse events compared with plasma exchange (very low certainty).

1 finding from 1 review

Eculizumab vs placebo

Participants with 1 or more serious adverse events · adults with severe Guillain‐Barré syndrome (GBS disability score > 2), within 2 weeks form onset

Eculizumab showed no clear difference in participants with 1 or more serious adverse events compared with placebo (low certainty).

1 finding from 1 review

Interferon beta‐1a vs placebo

Participants with 1 or more serious adverse events · patients with Guillain‐Barré syndrome

It is very uncertain whether interferon beta‐1a changes participants with 1 or more serious adverse events compared with placebo (very low certainty).

1 finding from 1 review

IVIg vs PE

Number of patients with adverse events attributed to treatment · patients with Guillain‐Barré syndrome

IVIg showed no clear difference in number of participants with adverse events attributed to treatment compared with PE (moderate certainty).

1 finding from 1 review