Findings

What do systematic reviews say?

3 questions · 3 findings · 2 reviews · Emergency and Critical Care

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No studies found 1 · 33.3%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 1 · 33.3%High 1 · 33.3%

Corticosteroids vs placebo or usual care

Number of participants with adverse events ‐ superinfection (up to longest · children and adults with sepsis

Corticosteroids showed no clear difference in number of participants with adverse events ‐ superinfection (up to… compared with placebo or usual care (moderate certainty).

1 finding from 1 review

Corticosteroids for treating sepsis in children and adults 2019 · Cochrane Headline outcomes only
RR 1.06 [0.95, 1.19]
25 studies · 5356 participants
Moderate

Corticosteroids vs placebo or usual care

Number of participants with adverse events ‐ muscle weakness (up to longest · children and adults with sepsis

Corticosteroids leads to higher number of participants with adverse events ‐ muscle weakness (up to… compared with placebo or usual care (high certainty).

1 finding from 1 review

Corticosteroids for treating sepsis in children and adults 2019 · Cochrane Headline outcomes only
RR 1.21 [1.01, 1.44]
6 studies · 6145 participants
High

Corticosteroids vs control

Adverse events Defined as leading to discontinuation of study medication; or for studies with standard care control, defined by study authors as "serious adverse events" · adults with acute respiratory distress syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological agents for adults with acute respiratory distress syndrome 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found