Findings

What do systematic reviews say?

5 questions · 5 findings · 3 reviews

No studies found 1 · 20%GRADE not reported 2 · 40%Very low 0 · 0%Low 1 · 20%Moderate 1 · 20%High 0 · 0%

Adverse events · Adults with periodontitis (chronic and aggressive)

Clarithromycin + SRP showed no clear difference in adverse events compared with SRP; GRADE not reported.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Both included trials reported adverse events in the clarithromycin + SRP group: unpalatable taste and mild gastric intolerance in 2 patients (Pradeep 2011); mild gastrointestinal discomfort in 2 patients (Rebelatto…
Studies not reported
GRADE not reported

Number of participants with any adverse events№ of participants: 10(1 RCT) · idiopathic hypersomnia

Clarithromycin showed no clear difference in number of participants with any adverse events№ of participants:… compared with placebo (low certainty).

1 finding from 1 review

Medications for daytime sleepiness in individuals with idiopathic hypersomnia 2021 · Cochrane Headline outcomes only
OR 0.41 [0.01, 12.64]
Studies not reported
Low

Serious adverse events, i.e. serious enough to require withdrawal of the treatment · pityriasis rosea

1 finding from 1 review

Interventions for pityriasis rosea 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Moderate

Minor adverse events not leading to withdrawal of treatment · pityriasis rosea

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for pityriasis rosea 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Adverse events · Adults with aggressive periodontitis

Amoxicillin + metronidazole + SRP showed no clear difference in adverse events compared with clarithromycin + SRP; GRADE not reported.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Two patients were reported to have vomiting and unbearable stomach pain in the AMOX + MTZ + SRP group (Araujo 2019).
1 study
GRADE not reported