Findings

What do systematic reviews say?

3 questions · 3 findings · 1 reviews · Urology

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 33.3%Low 0 · 0%Moderate 2 · 66.7%High 0 · 0%

Bisphosphonates vs placebo/no treatment

Adverse events: renal · men with advanced prostate cancer

Bisphosphonates probably leads to higher adverse events: renal compared with placebo/no treatment (moderate certainty).

1 finding from 1 review

Bisphosphonates for advanced prostate cancer 2017 · Cochrane Headline outcomes only
RR 1.65 [1.11, 2.46]
7 studies · 1794 participants
Moderate

Bisphosphonates vs placebo/no treatment

Adverse events: nausea · men with advanced prostate cancer

Bisphosphonates showed no clear difference in adverse events: nausea compared with placebo/no treatment (moderate certainty).

1 finding from 1 review

Bisphosphonates for advanced prostate cancer 2017 · Cochrane Headline outcomes only
RR 1.19 [1, 1.41]
9 studies · 3008 participants
Moderate

Bisphosphonates vs placebo/no treatment

Adverse events: osteonecrosis of the jaw · men with advanced prostate cancer

It is very uncertain whether bisphosphonates changes adverse events: osteonecrosis of the jaw compared with placebo/no treatment (very low certainty).

1 finding from 1 review

Bisphosphonates for advanced prostate cancer 2017 · Cochrane Headline outcomes only
RR 1.92 [0.75, 4.9]
5 studies · 1626 participants
Very low