Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

19 questions · 19 findings · 6 reviews · Common Mental Disorders

No studies found 4 · 21.1%GRADE not reported 0 · 0%Very low 5 · 26.3%Low 9 · 47.4%Moderate 1 · 5.3%High 0 · 0%

Tricyclic antidepressants vs placebo

Adverse events (at 4, 6 or 12 weeks) · adults with insomnia

Tricyclic antidepressants showed no clear difference in adverse events (at 4, 6 or 12 weeks) compared with placebo (low certainty).

1 finding from 1 review

Abrupt discontinuation vs continuation of long‐term antidepressants

Adverse events · participants with depressive or anxiety disorders

It is very uncertain whether abrupt discontinuation changes adverse events compared with continuation of long‐term antidepressants (very low certainty).

1 finding from 1 review