Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

15 questions · 15 findings · 3 reviews · Neonatal

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 10 · 66.7%Low 0 · 0%Moderate 4 · 26.7%High 1 · 6.7%

Comparison 2: any simplified antibiotic regimen vs 7 days injectable benzylpenicillin + injectable gentamicin

Adverse events · neonates with possible serious bacterial infection

Comparison 2: any simplified antibiotic regimen showed no clear difference in adverse events compared with the standard antibiotic regimen (7 days injectable benzylpenicillin… (moderate certainty).

1 finding from 1 review

Comparison 2: 7 days oral amoxicillin + injectable gentamicin vs 7 days injectable benzylpenicillin + injectable gentamicin

Adverse events · neonates with possible serious bacterial infection

Comparison 2: 7 days oral amoxicillin + injectable gentamicin showed no clear difference in adverse events compared with 7 days injectable benzylpenicillin + injectable gentamicin (moderate certainty).

1 finding from 1 review

Comparison 2: 2 days injectable benzylpenicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Adverse events · neonates with possible serious bacterial infection

Comparison 2: 2 days injectable benzylpenicillin + injectable… showed no clear difference in adverse events compared with 7 days injectable benzylpenicillin + injectable gentamicin (moderate certainty).

1 finding from 1 review

Meropenem vs usual care

Serious adverse events maximum · newborns with late‐onset sepsis

It is very uncertain whether meropenem changes serious adverse events maximum compared with standard care (very low certainty).

1 finding from 1 review