Findings

What do systematic reviews say?

5 questions · 5 findings · 3 reviews · Skin

Sort:Best matchNewest Highest certainty Download CSV

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 40%Low 2 · 40%Moderate 1 · 20%High 0 · 0%

Serlopitant 0.25 mg vs placebo

Adverse events · chronic pruritus of unknown origin

It is very uncertain whether serlopitant 0.25 mg changes adverse events compared with placebo (very low certainty).

1 finding from 1 review

Interventions for chronic pruritus of unknown origin 2020 · Cochrane Headline outcomes only
RR 1.29 [0.75, 2.24]
1 study · 127 participants
Very low

Serlopitant 5 mg vs placebo

Adverse events · chronic pruritus of unknown origin

It is very uncertain whether serlopitant 5 mg changes adverse events compared with placebo (very low certainty).

1 finding from 1 review

Interventions for chronic pruritus of unknown origin 2020 · Cochrane Headline outcomes only
RR 1.48 [0.87, 2.5]
1 study · 127 participants
Very low

Hydroxyzine 25 mg vs placebo

Withdrawals due to adverse events · patients with chronic spontaneous urticaria

Hydroxyzine 25 mg showed no clear difference in adverse events leading to withdrawal: intermediate‐term duration of… compared with placebo (low certainty).

1 finding from 1 review

H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
RR 3.64 [0.77, 17.23]
2 studies · 270 participants
Low

Cetirizine 0.5 mg/kg/d vs placebo (18‐month intervention)

Primary outcome 2. Proportion of participants reporting adverse effects and serious adverse events throughout the study period · children with eczema

Cetirizine 0.5 mg/kg/d showed no clear difference in primary outcome 2. Proportion of participants reporting adverse… compared with placebo (18‐month intervention) (moderate certainty).

1 finding from 1 review

Oral H1 antihistamines as ‘add‐on’ therapy to topical treatment for eczema 2019 · Cochrane Headline outcomes only
RR 0.68 [0.46, 1.01]
1 study · 795 participants
Moderate

Cetirizine 10 mg/d vs hydroxyzine 25 mg

Withdrawals due to adverse events · patients with chronic spontaneous urticaria

Cetirizine 10 mg showed no clear difference in adverse events leading to withdrawal compared with hydroxyzine 25 mg (low certainty).

1 finding from 1 review

H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
RR 0.78 [0.25, 2.45]
2 studies · 261 participants
Low