Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

193 questions · 195 findings · 93 reviews

No studies found 39 · 20%GRADE not reported 18 · 9.2%Very low 50 · 25.6%Low 40 · 20.5%Moderate 33 · 16.9%High 15 · 7.7%

Cyclosporin vs mycophenolate mofetil with pulse dexamethasone

Adverse events: hypertension · idiopathic steroid‐resistant nephrotic syndrome in children

Cyclosporin showed no clear difference in adverse events (weeks 0 to 26): hypertension compared with mycophenolate mofetil with pulse dexamethasone (low certainty).

1 finding from 1 review

Subcutaneous CT‐P13 and purine analogues vs intravenous CT‐P13 and purine analogues

Withdrawals due to adverse events · patients with Crohn's disease (active disease population with clinical response at baseline)

It is very uncertain whether subcutaneous CT‐P13 and purine analogues changes withdrawal due to adverse events (at 30 weeks) compared with intravenous CT‐P13 and purine analogues (very low certainty).

1 finding from 1 review

Infliximab vs placebo

Withdrawals due to adverse events · patients with Crohn's disease (mixed disease activity population with clinical response at baseline)

It is very uncertain whether infliximab changes withdrawal due to adverse events (at 32‐54 weeks) compared with placebo (very low certainty).

1 finding from 1 review

Beclometasone vs placebo

Adverse events: candidiasis · participants with stable stage 2 and 3 COPD (mainly FEV1 49 ± 12% predicted), ex‐smokers (majority), smokers and non‐smokers

It is very uncertain whether beclometasone changes adverse events: candidiasis compared with placebo (very low certainty).

1 finding from 1 review

Resin-based fissure sealant vs Fluoride varnish

Safety of sealants and fluoride varnishes (adverse events) · Children and adolescents (general population, aged under 20 years)
1 finding from 1 review

Antibiotics vs placebo

Serious adverse events WMD of · Adults (aged 40 or over) with COPD presenting with 1 or more exacerbations in the previous year. The 2 larger studies (Albert 2011; Sethi…

Antibiotics showed no clear difference in serious adverse events WMD of compared with placebo (moderate certainty).

1 finding from 1 review

Enteral vs enteral and parenteral nutrition

Adverse events: sepsis (as reported by study authors at end of study · critically ill adults admitted to the ICU for trauma, emergency, or post‐surgical care; population excludes participants with acute…

The review found no eligible studies for this question.

1 finding from 1 review

Enteral vs parenteral nutrition

Adverse events: sepsis (as reported by study authors at end of study · critically ill adults admitted to the ICU for trauma, emergency, or post‐surgical care; population excludes participants with acute…

Enteral may leads to lower adverse events: sepsis (as reported by study authors at end of study compared with parenteral nutrition (low certainty).

1 finding from 1 review

Enteral vs enteral and parenteral nutrition

Adverse events: Vomiting · critically ill adults admitted to the ICU for trauma, emergency, or post‐surgical care; population excludes participants with acute…

The review found no eligible studies for this question.

1 finding from 1 review

Enteral vs parenteral nutrition

Adverse events: Vomiting · critically ill adults admitted to the ICU for trauma, emergency, or post‐surgical care; population excludes participants with acute…

It is very uncertain whether enteral changes adverse events: vomiting (as reported by study authors at end of study compared with parenteral nutrition (very low certainty).

1 finding from 1 review

Enteral vs enteral and parenteral nutrition

Adverse events ‐ pneumonia · critically ill adults admitted to the ICU for trauma, emergency, or post‐surgical care; population excludes participants with acute…

It is very uncertain whether enteral changes adverse events: pneumonia (as reported by study authors at end of… compared with enteral and parenteral nutrition (very low certainty).

1 finding from 1 review