Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

185 questions · 187 findings · 30 reviews

No studies found 32 · 17.1%GRADE not reported 4 · 2.1%Very low 58 · 31%Low 59 · 31.6%Moderate 29 · 15.5%High 5 · 2.7%

Adalimumab vs placebo

Withdrawals due to adverse events · Participants with Crohn's disease in remission

Adalimumab probably leads to lower withdrawals due to adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Intervention not reported

Withdrawals due to adverse events · Patients with active Crohn's disease

The intervention showed no clear difference in withdrawals due to adverse events (low certainty).

1 finding from 1 review

Azathioprine or 6‐mercaptopurine vs mesalazine or sulfasalazine

Withdrawals due to adverse events · maintenance of remission in Crohn's disease

It is very uncertain whether azathioprine or 6‐mercaptopurine changes withdrawals due to adverse events compared with mesalazine or sulfasalazine (very low certainty).

1 finding from 1 review