Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

230 questions · 231 findings · 98 reviews

No studies found 73 · 31.6%GRADE not reported 10 · 4.3%Very low 71 · 30.7%Low 50 · 21.6%Moderate 20 · 8.7%High 7 · 3%

Oestrogen cream vs other regimens

Adverse events (total adverse events) (oestrogen cream vs non‐hormonal lubricant gel) · postmenopausal women with vaginal atrophy

Oestrogen cream showed no clear difference in adverse events (total adverse events) (oestrogen cream vs… compared with other regimens (low certainty).

1 finding from 1 review

Lidocaine vs disopyramide

Adverse events (AEs; adverse drug reaction): cardiac blocks (high‐degree atrioventricular block and bundle) · patients with myocardial infarction

It is very uncertain whether lidocaine changes adverse events (AEs; adverse drug reaction): cardiac blocks… compared with disopyramide (very low certainty).

1 finding from 1 review

Electromagnetic‐guided vs endoscopic‐guided postpyloric placement of nasoenteral feeding tubes

Adverse events

Electromagnetic‐guided showed no clear difference in adverse events compared with endoscopic‐guided postpyloric placement of nasoenteral feeding tubes (moderate certainty).

1 finding from 1 review

Intervention not reported

Adverse events · ≥ 15‐year‐old people with late second stage human African gambiense trypanosomiasis (trypanosomes in blood or nymph node fluid and WBC >…

The intervention showed no clear difference in adverse events (moderate certainty).

1 finding from 1 review

Biological therapy vs placebo, best supportive care (BSC) or no treatment

Any adverse events · advanced gastric and oesophago‐gastric junction adenocarcinoma

Biological therapy showed no clear difference in any adverse events compared with placebo, best supportive care (BSC) or no treatment (high certainty).

1 finding from 1 review

Chemmotherapy combined with biological therapy vs chemotherapy alone

Any adverse events · advanced gastric and oesophago‐gastric junction adenocarcinoma

Chemmotherapy combined with biological therapy showed no clear difference in any adverse events compared with chemotherapy (moderate certainty).

1 finding from 1 review

Chemotherapy vs placebo, best supportive care (BSC) or no treatment

Any adverse events · advanced gastric and oesophago‐gastric junction adenocarcinoma

Chemotherapy showed no clear difference in any adverse events compared with placebo, best supportive care (BSC) or no treatment (high certainty).

1 finding from 1 review