Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,041 questions · 1,056 findings · 283 reviews

No studies found 346 · 32.8%GRADE not reported 111 · 10.5%Very low 326 · 30.9%Low 195 · 18.5%Moderate 66 · 6.3%High 12 · 1.1%

Percutaneous nephrolithotripsy vs tubeless percutaneous nephrolithotripsy

Serious adverse events or complications of treatments

It is very uncertain whether percutaneous nephrolithotripsy changes serious adverse events or complications of treatments compared with tubeless percutaneous nephrolithotripsy (very low certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 14 weeks vs sdNVP plus ZDV (1 week)

Infants with Probably Related Severe Adverse Events · Breastfeeding infants of HIV‐infected mothers

It is very uncertain whether an extended NVP regimen administered to infants for 14 weeks changes infants with Probably Related Severe Adverse Events11 compared with sdNVP plus ZDV (1week) (very low certainty).

1 finding from 1 review

Group A: amino acids vs placebo

Adverse effects: suicidal thoughts (events) · people in the prodromal stage of psychosis

It is very uncertain whether group A: amino acids changes adverse effects: suicidal thoughts Short‐term (events) compared with placebo (very low certainty).

1 finding from 1 review

Monthly pegloticase vs placebo

Withdrawals due to adverse events · participants with tophi in gout

Monthly pegloticase probably leads to higher number of participant withdrawals due to adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Lesinurad 400 mg plus febuxostat CONTINUED vs lesinurad 200 mg plus febuxostat CONTINUED

Withdrawals due to adverse events · participants with tophi in gout

Lesinurad 400 mg plus febuxostat CONTINUED showed no clear difference in number of participant withdrawals due to adverse events compared with lesinurad 200 mg plus febuxostat CONTINUED (low certainty).

1 finding from 1 review

Pegloticase every two weeks (biweekly) vs placebo

Withdrawals due to adverse events · participants with tophi in gout

Pegloticase every two weeks (biweekly) probably leads to higher number of participant withdrawals due to adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Breastfeeding (post cleft-lip surgery) vs Spoon-feeding

Adverse events (wound dehiscence; lip scar hypertrophy) · Infants up to 6 months (from term) born with cleft lip, cleft palate or cleft lip and palate (Pierre Robin sequence or other syndromes…
1 finding from 1 review