Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

150 questions · 150 findings · 48 reviews

No studies found 19 · 12.7%GRADE not reported 21 · 14%Very low 40 · 26.7%Low 39 · 26%Moderate 23 · 15.3%High 8 · 5.3%

Oral retinoids: alitretinoin 10 mg vs placebo

Primary outcome 3: Adverse events · people with moderate to severe chronic hand eczema

Oral retinoids: alitretinoin 10 mg showed no clear difference in primary: all adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Convalescent plasma vs placebo or usual care

Grades 3 and 4 adverse events · individuals with moderate to severe disease

Summary of findings table ‐ Convalescent plasma showed no clear difference in grades 3 and 4 adverse events compared with placebo or standard care alone (low certainty).

1 finding from 1 review

Inulin and oligofructose 15 g vs inulin and oligofructose 7.5 g daily

Total adverse events (9 weeks) · Patients with active mild to moderate ulcerative colitis

It is very uncertain whether inulin and oligofructose 15 g changes total adverse events (9 weeks) compared with inulin and oligofructose 7.5 g daily (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Convalescent plasma vs placebo or usual care

Serious adverse events ‐ total · individuals with moderate to severe disease

Summary of findings table ‐ Convalescent plasma showed no clear difference in serious adverse events ‐ total compared with placebo or standard care alone (moderate certainty).

1 finding from 1 review

Hydromorphone vs morphine

Nausea · people with moderate to severe cancer pain

It is very uncertain whether hydromorphone changes specific adverse events – nausea compared with morphine (very low certainty).

1 finding from 1 review

Hydromorphone vs fentanyl

Nausea · people with moderate to severe cancer pain

The review found no eligible studies for this question.

1 finding from 1 review

Hydromorphone vs oxycodone

Nausea · people with moderate to severe cancer pain

It is very uncertain whether hydromorphone changes specific adverse events – nausea compared with oxycodone (very low certainty).

1 finding from 1 review