Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

42 questions · 42 findings · 21 reviews

No studies found 10 · 23.8%GRADE not reported 1 · 2.4%Very low 11 · 26.2%Low 6 · 14.3%Moderate 13 · 31%High 1 · 2.4%

Omega‐3 fatty acids and antioxidants vs standard diet or placebo

Gastrointestinal adverse events · adults (aged 18 years or older), mechanically ventilated participants with ARDS as defined by the Berlin definition of ARDS or, for older…

It is very uncertain whether omega‐3 fatty acids and antioxidants changes gastrointestinal adverse events (study author reported anytime… compared with placebo or standard nutrition (very low certainty).

1 finding from 1 review

Loratadine 10 mg vs placebo (4‐week intervention)

Primary outcome 2. Proportion of participants reporting adverse effects and serious adverse events throughout the study period · adults with eczema

Loratadine 10 mg/d showed no clear difference in primary outcome 2. Proportion of participants reporting adverse… compared with placebo (4‐week intervention) (low certainty).

1 finding from 1 review