Findings

What do systematic reviews say?

44 questions · 45 findings · 19 reviews

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No studies found 11 · 24.4%GRADE not reported 2 · 4.4%Very low 11 · 24.4%Low 14 · 31.1%Moderate 2 · 4.4%High 5 · 11.1%

Intervention not reported

Adverse events (serious ‐ resulting in hospitalisation or death) · adults aged ≥ 18 years with a diagnosis of glenohumeral osteoarthritis who have not responded to non‐operative treatments

1 finding from 1 review

Shoulder replacement surgery for osteoarthritis and rotator cuff tear arthropathy 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 42 participants
Very low

Cipaglucosidase plus miglustat vs alglucosidase alfa plus placebo

Treatment‐related AEs: total treatment‐emergent adverse events potentially related to treatment · adults with LOPD

Cipaglucosidase plus miglustat showed no clear difference in treatment‐related AEs: total treatment‐emergent adverse events… compared with alglucosidase alfa plus placebo (low certainty).

1 finding from 1 review

Enzyme replacement therapy for late‐onset Pompe disease 2023 · Cochrane Headline outcomes only
RR 0.83 [0.49, 1.4]
1 study · 123 participants
Low

Avalglucosidase alfa vs alglucosidase alfa

Treatment‐related AEs: total treatment‐emergent adverse events potentially related to treatment · adults with LOPD

Avalglucosidase alfa showed no clear difference in treatment‐related AEs: total treatment‐emergent adverse events… compared with alglucosidase alfa (low certainty).

1 finding from 1 review

Enzyme replacement therapy for late‐onset Pompe disease 2023 · Cochrane Headline outcomes only
RR 0.92 [0.61, 1.4]
1 study · 100 participants
Low

Thyroxine vs placebo or no treatment

Adverse events including maternal pregnancy complications, foetal complications and adverse effects of thyroxine · subfertile women with euthyroid autoimmune thyroid disease or subclinical hypothyroidism

Thyroxine led to lower adverse events including maternal pregnancy complications, foetal… compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Thyroxine replacement for subfertile women with euthyroid autoimmune thyroid disease or subclinical hypothyroidism 2019 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 1 participants
GRADE not reported