Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

50 questions · 50 findings · 21 reviews

No studies found 7 · 14%GRADE not reported 3 · 6%Very low 18 · 36%Low 15 · 30%Moderate 3 · 6%High 4 · 8%

Usual care vs immunosuppressive withdrawal after monotherapy

Withdrawals due to adverse events · Participants with Crohn's disease in remission

It is very uncertain whether usual care changes withdrawal due to adverse events compared with immunosuppressive withdrawal after monotherapy (very low certainty).

1 finding from 1 review

Oral + inhaled dual therapy vs oral monotherapy

Serious adverse events. Outcome assessed on day 42 · bronchiectasis

It is very uncertain whether oral + inhaled dual therapy changes serious adverse events. Outcome assessed on day 42 compared with oral monotherapy (very low certainty).

1 finding from 1 review

Rituximab (2 x 1000 mg) plus methotrexate vs methotrexate

Discontinuation of medication due to adverse events · patients with rheumatoid arthritis

Rituximab (2 x 1000 mg) plus methotrexate showed no clear difference in discontinuations due to adverse events Analysis 6.3 compared with methotrexate monotherapy (moderate certainty).

1 finding from 1 review