Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

196 questions · 197 findings · 80 reviews

No studies found 45 · 22.8%GRADE not reported 15 · 7.6%Very low 42 · 21.3%Low 49 · 24.9%Moderate 36 · 18.3%High 10 · 5.1%

Fixed‐dose combination aclidinium/formoterol vs formoterol

Adverse events (not including serious adverse events): number of participants · patients with chronic obstructive pulmonary disease

Fixed‐dose combination aclidinium/formoterol leads to lower adverse events (not including serious adverse events): number of… compared with formoterol (high certainty).

1 finding from 1 review

Fixed‐dose combination aclidinium/formoterol vs placebo

Adverse events (not including serious adverse events): number of participants · patients with chronic obstructive pulmonary disease

Fixed‐dose combination aclidinium/formoterol showed no clear difference in adverse events (not including serious adverse events): number of… compared with placebo (moderate certainty).

1 finding from 1 review

Fixed‐dose combination aclidinium/formoterol vs aclidinium alone

Adverse events (not including serious adverse events): number of participants · patients with chronic obstructive pulmonary disease

Fixed‐dose combination aclidinium/formoterol showed no clear difference in adverse events (not including serious adverse events): number of… compared with aclidinium alone (moderate certainty).

1 finding from 1 review

Intervention not reported

Adverse events-serious events Budesonide/formoterol (BDF) versus budesonide (BD) · patients with COPD

It is very uncertain whether the intervention changes adverse events-serious events Budesonide/formoterol (BDF) versus… (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse outcome: unintended adverse events attributable to the intervention ATCS+, IVR, unidirectional versus various controls · participants at risk of under‐immunisation (children, adolescents and adults)

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Behavioural outcome: adherence to medication or composite outcome (medication adherence and rate of adverse events) ATCS Plus versus usual care · patients with various conditions or at risk of low adherence to medication or laboratory tests
1 finding from 1 review

Intervention not reported

Adverse outcome: unintended adverse events attributable to the intervention Multimodal/complex intervention, ATCS Plus, IVR, unidirectional versus various controls · participants at risk for breast, colorectal or cervical cancer; or osteoporosis

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Adverse outcome: unintended adverse events attributable to the intervention Multimodal/complex intervention, ATCS Plus, IVR, unidirectional versus various controls · patients with various conditions or at risk of low adherence to medication or laboratory tests

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Adverse outcome: unintended adverse events attributable to the intervention Multimodal/complex intervention, ATCS Plus, IVR, unidirectional ATCS versus various controls · patients with hypertension

The review found no eligible studies for this question.

1 finding from 1 review