Findings

What do systematic reviews say?

2 questions · 2 findings · 1 reviews · Headline outcomes only

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 50%Moderate 1 · 50%High 0 · 0%

Minor adverse events · patients with cutaneous disease in systemic lupus erythematosus

Oral methotrexate may leads to higher adverse events: minor compared with oral chloroquine (low certainty).

1 finding from 1 review

Interventions for cutaneous disease in systemic lupus erythematosus 2021 · Cochrane Headline outcomes only
RR 3.9 [1.45, 10.51]
1 study · 41 participants
Low

Minor adverse events · patients with cutaneous disease in systemic lupus erythematosus

Oral methotrexate showed no clear difference in adverse events: minor compared with placebo (moderate certainty).

1 finding from 1 review

Interventions for cutaneous disease in systemic lupus erythematosus 2021 · Cochrane Headline outcomes only
RR 0.68 [0.39, 1.17]
1 study · 86 participants
Moderate