Findings

What do systematic reviews say?

1 questions · 1 findings · 1 reviews · Neuromuscular

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 1 · 100%High 0 · 0%

Withdrawals due to adverse events · neuropathic pain (two studies found in painful diabetic neuropathy, and one in lumbar radiculopathy)

Topiramate 200 to 400 mg probably leads to higher adverse event withdrawals compared with placebo (moderate certainty).

1 finding from 1 review

Topiramate for neuropathic pain and fibromyalgia in adults 2013 · Cochrane Headline outcomes only
RR 3.4 [4.3, 7.1]
1038 participants
Moderate