What do systematic reviews say?

Omega‐3 vs placebo

It is very uncertain whether omega‐3 changes adverse effects (any adverse effect) compared with placebo (very low certainty).

• Antioxidant supplementation for sickle cell disease 2024 · Cochrane Headline outcomes only
  RR 1.05 [0.74, 1.48]
  1 study · 67 participants
  Very low

Prophylaxis with standard therapeutic factor concentrate vs pegylated liposome FVIII formulation

• Clotting factor concentrates for preventing bleeding and bleeding‐related complications in previously treated… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 143 participants
  Low

Full‐mouth ultrasonic scaling plus photodynamic therapy vs full‐mouth ultrasonic scaling alone

The review found no eligible studies for this question.

• Treatment of dental and orthodontic complications in thalassaemia 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Inhaled tobramycin (TNS) plus oral azithromycin vs TNS plus oral placebo

Inhaled tobramycin (TNS) plus oral azithromycin showed no clear difference in adverse effects of antibiotics: number of participants experiencing… compared with TNS plus oral placebo (moderate certainty).

• Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis 2023 · Cochrane Headline outcomes only
  RR 1.05 [0.96, 1.14]
  1 study · 221 participants
  Moderate