Findings

What do systematic reviews say?

11 questions · 11 findings · 4 reviews · Headline outcomes only

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No studies found 0 · 0%GRADE not reported 2 · 18.2%Very low 0 · 0%Low 0 · 0%Moderate 2 · 18.2%High 7 · 63.6%

Hypofractionated radiotherapy vs daily conventionally fractionated radiotherapy

Adverse effects · high‐grade glioma

1 finding from 1 review

External beam radiation dose escalation for high grade glioma 2020 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 848 participants
GRADE not reported

Daily conventionally fractionated radiotherapy vs supportive care

Adverse effects · high‐grade glioma

1 finding from 1 review

External beam radiation dose escalation for high grade glioma 2020 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 289 participants
GRADE not reported

Hyperbaric oxygen vs air breathing

Adverse effects · People undergoing radiotherapy for uterine cervical cancer

Hyperbaric oxygen leads to higher adverse effects compared with air breathing (high certainty).

1 finding from 1 review

Hyperbaric oxygenation for tumour sensitisation to radiotherapy 2018 · Cochrane Headline outcomes only
RR 2.05 [1.22, 3.46]
3 studies · 456 participants
High

Hyperbaric oxygen vs air breathing to enhance the effectiveness of radiotherapy

Adverse effects · People undergoing radiation therapy for head and neck cancer

Hyperbaric oxygen probably leads to higher adverse effects compared with air breathing to enhance the effectiveness of radiotherapy (moderate certainty).

1 finding from 1 review

Hyperbaric oxygenation for tumour sensitisation to radiotherapy 2018 · Cochrane Headline outcomes only
RR 2.64 [1.65, 4.23]
4 studies · 323 participants
Moderate

Brachytherapy vs brachytherapy plus radiotherapy

Adverse effects · patients with dysphagia in oesophageal cancer

Brachytherapy showed no clear difference in adverse effects compared with brachytherapy plus radiotherapy (moderate certainty).

1 finding from 1 review

Interventions for dysphagia in oesophageal cancer 2014 · Cochrane Headline outcomes only
OR 1.17 [0.44, 3.15]
2 studies · 554 participants
Moderate

Hyperbaric oxygen vs air breathing

Adverse effects · People with any one of a mixed group of cancers

Hyperbaric oxygen leads to higher adverse effects compared with air breathing (high certainty).

1 finding from 1 review

Hyperbaric oxygenation for tumour sensitisation to radiotherapy 2018 · Cochrane Headline outcomes only
RR 2.35 [1.66, 3.33]
7 studies · 779 participants
High

Brachytherapy vs brachytherapy plus radiotherapy

Adverse effects ‐ stricture · patients with dysphagia in oesophageal cancer

Brachytherapy showed no clear difference in adverse effects ‐ stricture compared with brachytherapy plus radiotherapy (high certainty).

1 finding from 1 review

Interventions for dysphagia in oesophageal cancer 2014 · Cochrane Headline outcomes only
OR 1.43 [0.16, 12.85]
2 studies · 277 participants
High

Whole brain radiation therapy (WBRT) + stereotactic radiosurgery (SRS) vs WBRT

Adverse effectsNo. of participants: 1754(9 RCTs) · patients with newly diagnosed multiple brain metastases

1 finding from 1 review

Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
High

Radiosurgery alone vs WBRT and radiosurgery

Adverse effectsNo. of participants: 1754(9 RCTs) · patients with newly diagnosed multiple brain metastases

1 finding from 1 review

Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
High

WBRT with radiosensitisers (radiosen) vs WBRT

Adverse effectsNo. of participants: 1754(9 RCTs) · patients with newly diagnosed multiple brain metastases

1 finding from 1 review

Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
High

Altered WBRT fractionation schedules vs WBRT control

Adverse effectsNo. of participants: 1754(9 RCTs) · patients with newly diagnosed multiple brain metastases

1 finding from 1 review

Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
High