What do systematic reviews say?

Toric intraocular lens (IOL) vs limbal relaxing incisions (LRIs)

• Toric intraocular lens versus limbal relaxing incisions for corneal astigmatism after phacoemulsification 2019 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 318 participants
  Very low

Pentoxifylline (oral 400 mg thrice daily) plus meglumine antimoniate (IMMA) (20 mg/ kg /day for 20 days) vs IMMA plus placebo

• Interventions for American cutaneous and mucocutaneous leishmaniasis 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 70 participants
  Moderate

Hyperbaric oxygen vs air breathing

Hyperbaric oxygen leads to higher adverse effects compared with air breathing (high certainty).

• Hyperbaric oxygenation for tumour sensitisation to radiotherapy 2018 · Cochrane Headline outcomes only
  RR 2.05 [1.22, 3.46]
  3 studies · 456 participants
  High

Hyperbaric oxygen vs air breathing

Hyperbaric oxygen leads to higher adverse effects compared with air breathing (high certainty).

• Hyperbaric oxygenation for tumour sensitisation to radiotherapy 2018 · Cochrane Headline outcomes only
  RR 2.35 [1.66, 3.33]
  7 studies · 779 participants
  High

Hyperbaric oxygen vs air breathing to enhance the effectiveness of radiotherapy

Hyperbaric oxygen probably leads to higher adverse effects compared with air breathing to enhance the effectiveness of radiotherapy (moderate certainty).

• Hyperbaric oxygenation for tumour sensitisation to radiotherapy 2018 · Cochrane Headline outcomes only
  RR 2.64 [1.65, 4.23]
  4 studies · 323 participants
  Moderate

Uric acid lowering therapies (UAR) vs placebo

Uric acid‐lowering drug showed no clear difference in adverse events (withdrawals due to side effects) compared with placebo (low certainty).

• Pharmacotherapy for hyperuricaemia in hypertensive patients 2020 · Cochrane Headline outcomes only
  RR 1.86 [0.43, 8.1]
  3 studies · 241 participants
  Low

Electrical stimulation vs pelvic floor muscle training (PFMT)

Electrical stimulation showed no clear difference in adverse effects compared with pelvic floor muscle training (low certainty).

• Electrical stimulation with non‐implanted devices for stress urinary incontinence in women 2017 · Cochrane Headline outcomes only
  RR 5 [0.25, 99.16]
  3 studies · 121 participants
  Low

Electrical stimulation vs vaginal cones alone

Electrical stimulation showed no clear difference in adverse effects compared with vaginal cones (low certainty).

• Electrical stimulation with non‐implanted devices for stress urinary incontinence in women 2017 · Cochrane Headline outcomes only
  RR 0.54 [0.11, 2.7]
  1 study · 52 participants
  Low

Electrical stimulation vs PFMT plus vaginal cones

The review found no eligible studies for this question.

• Electrical stimulation with non‐implanted devices for stress urinary incontinence in women 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Electrical stimulation vs drug therapy

The review found no eligible studies for this question.

• Electrical stimulation with non‐implanted devices for stress urinary incontinence in women 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Electrical stimulation vs No active treatment (control)

It is very uncertain whether electrical stimulation changes adverse effects compared with no active treatment (very low certainty).

• Electrical stimulation with non‐implanted devices for stress urinary incontinence in women 2017 · Cochrane Headline outcomes only
  RR 5.96 [0.3, 118.7]
  3 studies · 103 participants
  Very low

Electrical stimulation vs sham

Electrical stimulation showed no clear difference in adverse effects compared with sham treatment (low certainty).

• Electrical stimulation with non‐implanted devices for stress urinary incontinence in women 2017 · Cochrane Headline outcomes only
  RR 2.01 [0.52, 7.67]
  4 studies · 233 participants
  Low

Electrical stimulation vs pelvic floor muscle training (PFMT)

• Electrical stimulation with non‐implanted electrodes for overactive bladder in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Electrical stimulation vs pelvic floor muscle training (PFMT) plus biofeedback

• Electrical stimulation with non‐implanted electrodes for overactive bladder in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Electrical stimulation vs magnetic stimulation alone

• Electrical stimulation with non‐implanted electrodes for overactive bladder in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 32 participants
  Very low

Electrical stimulation vs laseropuncture/electro‐acupuncture

• Electrical stimulation with non‐implanted electrodes for overactive bladder in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Electrical stimulation vs No active treatment (control)

• Electrical stimulation with non‐implanted electrodes for overactive bladder in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Electrical stimulation vs Placebo / sham solution

Electrical stimulation showed no clear difference in adverse effects compared with placebo or sham treatment (low certainty).

• Electrical stimulation with non‐implanted electrodes for overactive bladder in adults 2016 · Cochrane Headline outcomes only
  RR 1.24 [0.84, 1.83]
  3 studies · 450 participants
  Low

Prefabricated foot orthoses vs shoes

The review found no eligible studies for this question.

• Foot orthoses for treating paediatric flat feet 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

PFMT added to electrical stimulation vs pelvic floor muscle training (PFMT)

• Electrical stimulation with non‐implanted devices for stress urinary incontinence in women 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 133 participants
  Low