What do systematic reviews say?

Summary of findings ‐ withdrawal of penicillin prophylaxis vs continuation

Summary of findings ‐ withdrawal of penicillin prophylaxis showed no clear difference in adverse effects: incidences of nausea and vomiting compared with continuation (low certainty).

• Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease 2021 · Cochrane Headline outcomes only
  OR 1.99 [0.18, 22.12]
  1 study · 400 participants
  Low

Summary of findings ‐ initiation of penicillin prophylaxis vs placebo

• Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease 2021 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 457 participants
  Low

Antistaphylococcal cephalosporins C1 and C2 (1st and 2nd generation) vs broad spectrum penicillins plus betalactamase inhibitors P2+ ‐ all outcomes

It is very uncertain whether antistaphylococcal cephalosporins C1 and C2 (1st and 2nd generation) changes maternal composite adverse effects compared with broad spectrum penicillins plus betalactamase inhibitors P2+ ‐ all… (very low certainty).

• Different classes of antibiotics given to women routinely for preventing infection at caesarean section 2021 · Cochrane Headline outcomes only
  RR 0.96 [0.09, 10.5]
  2 studies · 468 participants
  Very low