Findings

What do systematic reviews say?

6 questions · 6 findings · 5 reviews · Dental caries

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No studies found 0 · 0%GRADE not reported 5 · 83.3%Very low 1 · 16.7%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Slow-release fluoride device (fluoride glass beads) vs Fluoride mouthrinse

Adverse effects · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

1 finding from 1 review

Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment 2019 · Cochrane All outcomes
At debond; follow-up 19 months
Additional SoF Table 3. Adverse effects: current design of the fluoride glass bead inadequate; high attrition partly due to bead breakages ('an improved method of attachment is needed'). 37 participants (1 RCT, Luther…
1 study · 37 participants
Very low

Oral irrigation plus toothbrushing vs Toothbrushing alone

Side effects · Adults, 16 years and older (dentate)

1 finding from 1 review

Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlling periodontal… 2019 · Cochrane All outcomes
Three studies reported that there were no adverse events, one reported one incidence of aphthous ulcer in irrigator group, one reported oral lacerations but found no difference between the interventions, and one did…
5 studies
GRADE not reported

Oral irrigation plus toothbrushing vs Flossing plus toothbrushing

Side effects · Adults, 16 years and older (dentate)

1 finding from 1 review

Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlling periodontal… 2019 · Cochrane All outcomes
Both studies reported that there were no adverse events in either study group.
2 studies
GRADE not reported

Topical fluoride therapy (toothpaste, mouthrinse, gel or varnish; any fluoride agent/concentration; frequency at least once a year) vs placebo or no treatment

Adverse effects (tooth staining/discoloration, oral soft-tissue signs, adverse symptoms such as nausea/vomiting, enamel etching) · Children and adolescents aged 16 years or less

1 finding from 1 review

Topical fluoride (toothpastes, mouthrinses, gels or varnishes) for preventing dental caries in children and adolescents 2003 · Cochrane All outcomes
Data on adverse effects (stain score, proportion of children with tooth staining, signs of sensitivity in oral soft tissue, adverse symptoms such as nausea/vomiting, etching of enamel) were reported in only a few…
Studies not reported
GRADE not reported

Fluoride varnish vs placebo or no treatment

Adverse effects / specific side effects (oral allergic reactions, mucosal irritation, adverse symptoms such as nausea, gagging, vomiting) · Children and adolescents aged 16 years or less

1 finding from 1 review

Fluoride varnishes for preventing dental caries in children and adolescents 2013 · Cochrane All outcomes
At least 1 year
Three trials (Salazar 2008; Skold 2005; Weintraub 2006) provided data reporting no adverse effects. There was little information concerning possible adverse effects; no pooled estimate was possible.
3 studies
GRADE not reported

Chemotherapy (any regimen; added to, or compared with, locoregional treatment) vs Locoregional treatment and/or an alternative chemotherapy regimen

Toxicity / adverse effects (harms) of chemotherapy · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer

1 finding from 1 review

Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy 2021 · Cochrane All outcomes
Harms/toxicity were planned but very little quantitative data suitable for analysis were found; toxicity reported narratively and not quantified or GRADE-rated.
Studies not reported
GRADE not reported