Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

87 questions · 112 findings · 34 reviews

No studies found 21 · 18.8%GRADE not reported 47 · 42%Very low 26 · 23.2%Low 13 · 11.6%Moderate 4 · 3.6%High 1 · 0.9%

Educational intervention with information and practical components (theoretical oral health education plus practical skills training) for nursing staff and/or residents vs (Optimised) usual care

Adverse effects of the interventions · Nursing home residents (mean age 78.3 to 86.0 years; more than 66% women; 62.1% to 87.3% with dental prostheses)

The review found no eligible studies for this question.

1 finding from 1 review

Neurohormones vs placebo

Adverse effects · participants (any age) with a clinical diagnosis of ASD who have displayed one or more unwanted or challenging behaviours at baseline…

It is very uncertain whether neurohormones changes adverse effects compared with placebo (very low certainty).

1 finding from 1 review

Summary of findings: multimedia education and a co‐intervention vs co‐intervention alone

Medication side effects Mean adverse self‐medication behaviour score (lower scores indicate safer self‐medication behaviour). Scale from: 0 to 40. · patients taking prescribed and over‐the‐counter medications or their carers
1 finding from 1 review

Herbal extracts (tea components; Chinese herbal mixture; freeze-dried black raspberry gel) vs placebo or no treatment

Safety of the intervention (adverse effects) · People with a diagnosis of oral leukoplakia
1 finding from 1 review
  • Interventions for treating oral leukoplakia to prevent oral cancer 2016 · Cochrane All outcomes
    up to 3 months
    SoF 4, Safety of the intervention up to 3 months: '3 studies measured adverse effects: green tea extract capsules caused high frequency (93%) of adverse effects of varying severity in 1 study; the mixed tea study did…
    3 studies
    GRADE not reported

LongoVital (herbal plus vitamin component) vs LongoVital (herbal component alone)

Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review

Oral methotrexate and oral prednisone vs prednisone or placebo

Adverse events associated with treatment · children and adolescents with active morphea (linear scleroderma, generalised morphea and mixed subtype: linear and circumscribed).

Oral methotrexate and oral prednisone showed no clear difference in primary outcome: Adverse effects compared with placebo and oral prednisone (low certainty).

1 finding from 1 review

Topical triamcinolone acetonide vs pimecrolimus 1%

Adverse effects · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

Topical triamcinolone acetonide showed no clear difference in adverse effects compared with topical pimecrolimus; GRADE not reported.

1 finding from 1 review