Findings

What do systematic reviews say?

7 questions · 7 findings · 2 reviews · ENT

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No studies found 2 · 28.6%GRADE not reported 0 · 0%Very low 1 · 14.3%Low 4 · 57.1%Moderate 0 · 0%High 0 · 0%

Sinonasal debridement vs no debridement

Significant adverse effects: significant bleeding requiring intervention, severe pain, iatrogenic injury · adult patients who underwent primary endoscopic sinus surgery, with a diagnosis of recurrent acute or chronic rhinosinusitis

The review found no eligible studies for this question.

1 finding from 1 review

Sinonasal debridement versus no debridement for the postoperative care of patients undergoing endoscopic sinus surgery 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical antifungal vs placebo/no treatment

Adverse effects: headache · chronic rhinosinusitis

It is very uncertain whether topical antifungal changes adverse effects ‐ headache compared with placebo/no treatment (very low certainty).

1 finding from 1 review

Topical and systemic antifungal therapy for chronic rhinosinusitis 2018 · Cochrane Headline outcomes only
RR 1.26 [0.6, 2.63]
Studies not reported
Very low

Topical antifungal vs placebo/no treatment

Adverse effects ‐ epistaxis · chronic rhinosinusitis

Topical antifungal showed no clear difference in adverse effects ‐ epistaxis compared with placebo/no treatment (low certainty).

1 finding from 1 review

Topical and systemic antifungal therapy for chronic rhinosinusitis 2018 · Cochrane Headline outcomes only
RR 0.97 [0.14, 6.63]
Studies not reported
Low

Systemic antifungal vs placebo/no treatment

Adverse effects ‐ hepatic toxicity · chronic rhinosinusitis

Systemic antifungal showed no clear difference in adverse effects ‐ hepatic toxicity compared with placebo/no treatment (low certainty).

1 finding from 1 review

Topical and systemic antifungal therapy for chronic rhinosinusitis 2018 · Cochrane Headline outcomes only
RR 3.35 [0.14, 78.6]
Studies not reported
Low

Topical antifungal vs placebo/no treatment

Other adverse effects: local irritation · chronic rhinosinusitis

Topical antifungal showed no clear difference in adverse effects ‐ local irritation compared with placebo/no treatment (low certainty).

1 finding from 1 review

Topical and systemic antifungal therapy for chronic rhinosinusitis 2018 · Cochrane Headline outcomes only
RR 2.29 [0.61, 8.62]
Studies not reported
Low

Systemic antifungal vs placebo/no treatment

Allergic adverse events · chronic rhinosinusitis

The review found no eligible studies for this question.

1 finding from 1 review

Topical and systemic antifungal therapy for chronic rhinosinusitis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Systemic antifungal vs placebo/no treatment

Gastrointestinal adverse events · chronic rhinosinusitis

Systemic antifungal showed no clear difference in adverse effects ‐ gastrointestinal disturbances compared with placebo/no treatment (low certainty).

1 finding from 1 review

Topical and systemic antifungal therapy for chronic rhinosinusitis 2018 · Cochrane Headline outcomes only
RR 0.37 [0.04, 3.36]
Studies not reported
Low