Findings

What do systematic reviews say?

4 questions · 4 findings · 4 reviews · Dental caries

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No studies found 1 · 25%GRADE not reported 3 · 75%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Adhesively bonded amalgam restorations in conventional preparations utilising deliberate retention (all bonding agents) vs Amalgam restoration

Adverse effects · Adults and adolescents with permanent posterior molar and premolar teeth suitable for Class I and II, but excluding Class V, amalgam…

The review found no eligible studies for this question.

1 finding from 1 review

Adhesively bonded versus non‐bonded amalgam restorations for dental caries 2016 · Cochrane All outcomes
Adverse effects: any event for which the causal relationship between the event and the amalgam restoration is at least a reasonable possibility - not measured | See comment | See comment | Not estimable | - | See…
0 studies
No studies found

Fluoride mouthrinse, gel or varnish combined with fluoride toothpaste (any combined regimen) vs Fluoride toothpaste alone

Adverse effects (tooth staining and other side effects) · Children and adolescents aged 16 years or less

1 finding from 1 review

Combinations of topical fluoride (toothpastes, mouthrinses, gels, varnishes) versus single topical fluoride for… 2004 · Cochrane All outcomes
Adverse-effect data scarcely reported: a stain score in one trial and 'any side effects' in one trial without complete or useable data (stated 'no side effects observed in both groups'). No useful information on tooth…
Studies not reported
GRADE not reported

Topical fluoride therapy (toothpaste, mouthrinse, gel or varnish; any fluoride agent/concentration; frequency at least once a year) vs placebo or no treatment

Adverse effects (tooth staining/discoloration, oral soft-tissue signs, adverse symptoms such as nausea/vomiting, enamel etching) · Children and adolescents aged 16 years or less

1 finding from 1 review

Topical fluoride (toothpastes, mouthrinses, gels or varnishes) for preventing dental caries in children and adolescents 2003 · Cochrane All outcomes
Data on adverse effects (stain score, proportion of children with tooth staining, signs of sensitivity in oral soft tissue, adverse symptoms such as nausea/vomiting, etching of enamel) were reported in only a few…
Studies not reported
GRADE not reported

Fluoride varnish vs placebo or no treatment

Adverse effects / specific side effects (oral allergic reactions, mucosal irritation, adverse symptoms such as nausea, gagging, vomiting) · Children and adolescents aged 16 years or less

1 finding from 1 review

Fluoride varnishes for preventing dental caries in children and adolescents 2013 · Cochrane All outcomes
At least 1 year
Three trials (Salazar 2008; Skold 2005; Weintraub 2006) provided data reporting no adverse effects. There was little information concerning possible adverse effects; no pooled estimate was possible.
3 studies
GRADE not reported