Findings

What do systematic reviews say?

4 questions · 4 findings · 2 reviews · Orthodontics

No studies found 2 · 50%GRADE not reported 1 · 25%Very low 1 · 25%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Side effects or other adverse events · Orthodontic patients (any age) undergoing orthodontic treatment (mostly fixed appliances)

No adverse effects were reported in any of the seven included studies (ungraded).

1 finding from 1 review

Fluoride mouthrinses for prevention of initial caries in orthodontic patients - a systematic review and meta-analysis. 2025 All outcomes
During treatment · Clinical orthodontic (fixed multi-bracket appliance) treatment
No side- or adverse effects were reported in any of the included reports.
7 studies · 704 participants
GRADE not reported

Adverse effects · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

1 finding from 1 review

Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment 2019 · Cochrane All outcomes
At debond; follow-up 19 months
Additional SoF Table 3. Adverse effects: current design of the fluoride glass bead inadequate; high attrition partly due to bead breakages ('an improved method of attachment is needed'). 37 participants (1 RCT, Luther…
1 study · 37 participants
Very low

Adverse effects · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

The review found no eligible studies for this question.

1 finding from 1 review

Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment 2019 · Cochrane All outcomes
At debond (end of orthodontic treatment)
Additional SoF Table 2. Adverse effects: none of the trials reported this outcome.
0 studies
No studies found

Adverse effects · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

The review found no eligible studies for this question.

1 finding from 1 review

Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment 2019 · Cochrane All outcomes
At debond (end of orthodontic treatment)
SoF 4. Adverse effects: none of the trials reported this outcome.
0 studies
No studies found