Findings

What do systematic reviews say?

8 questions · 8 findings · 2 reviews · Pregnancy and Childbirth

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No studies found 3 · 37.5%GRADE not reported 1 · 12.5%Very low 4 · 50%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Postnatal prophylaxis: LMWH vs no treatment/placebo

Adverse effects sufficient to stop treatment · women at increased risk of VTE in the early postpartum period

The review found no eligible studies for this question.

1 finding from 1 review

Venous thromboembolism prophylaxis for women at risk during pregnancy and the early postnatal period 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Heparin prophylaxis vs no treatment/placebo

Adverse effects sufficient to stop treatment · pregnant women at increased risk of VTE during pregnancy and the early postnatal period

It is very uncertain whether antenatal (± postnatal) prophylaxis: heparin (LMWH or UFH) changes adverse effects sufficient to stop treatment compared with no treatment/placebo (very low certainty).

1 finding from 1 review

Venous thromboembolism prophylaxis for women at risk during pregnancy and the early postnatal period 2021 · Cochrane Headline outcomes only
RR 0.49 [0.05, 5.31]
1 study · 139 participants
Very low

LMWH prophylaxis vs UFH

Adverse effects sufficient to stop treatment · pregnant women at increased risk of VTE during pregnancy and the early postnatal period

It is very uncertain whether antenatal (± postnatal) prophylaxis: LMWH changes adverse effects sufficient to stop treatment compared with UFH (very low certainty).

1 finding from 1 review

Venous thromboembolism prophylaxis for women at risk during pregnancy and the early postnatal period 2021 · Cochrane Headline outcomes only
RR 0.07 [0.01, 0.54]
2 studies · 226 participants
Very low

Peripartum/postnatal prophylaxis: UFH vs no treatment

Adverse effects sufficient to stop treatment · women with varicose veins before birth, having a caesarean (elective or emergency) or vaginal birth

The review found no eligible studies for this question.

1 finding from 1 review

Venous thromboembolism prophylaxis for women at risk during pregnancy and the early postnatal period 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Peripartum/postnatal prophylaxis (caesarean): heparin (LMWH or UFH) vs no treatment/placebo

Adverse effects sufficient to stop treatment · women giving birth by elective or emergency caesarean (elective only (1 trial), emergency or elective (4 trials))

1 finding from 1 review

Venous thromboembolism prophylaxis for women at risk during pregnancy and the early postnatal period 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 140 participants
Very low

Peripartum/postnatal prophylaxis (caesarean): LMWH vs UFH

Adverse effects sufficient to stop treatment · women giving birth by elective or emergency caesarean (elective or emergency (1 trial), elective cesarean only (1 trial),…

The review found no eligible studies for this question.

1 finding from 1 review

Venous thromboembolism prophylaxis for women at risk during pregnancy and the early postnatal period 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Chlorhexidine (vaginal wash or gel/cream) vs placebo or no treatment

Adverse (mild) effects in the mother · women with vaginal or rectal colonization with GBS during labour and their preterm/term infants

It is very uncertain whether chlorhexidine (vaginal wash or gel/cream) changes adverse (mild) effects in the mother compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Vaginal chlorhexidine during labour to prevent early‐onset neonatal group B streptococcal infection 2014 · Cochrane Headline outcomes only
RR 8.5 [1.6, 45.28]
3 studies · 1066 participants
Very low

Chlorhexidine (vaginal wash or gel/cream) vs placebo or no treatment

Adverse (mild) effects in the neonate · women with vaginal or rectal colonization with GBS during labour and their preterm/term infants

1 finding from 1 review

Vaginal chlorhexidine during labour to prevent early‐onset neonatal group B streptococcal infection 2014 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 1066 participants
GRADE not reported