Adverse effects: dental fluorosis · general population
The review found no eligible studies for this question.
1 finding from 1 review
Side effects · Adults, 16 years and older (dentate)
Harms and adverse outcomes (SoF): Neither study reported any information about adverse events. Jared 2005 assessed adverse events (participants issued a symptom diary) but did not report the findings; Graziani 2017 did…
1 study
GRADE not reported
Not estimable. Only 1 study reported adverse outcomes in terms of problems with the use of the assigned interdental cleaning aids. (See comment) In this comparison the single study (Jared 2005) asked participants to…
1 study
GRADE not reported
Side effects · Adults, 16 years and older (dentate)
Five studies reported there were no adverse events. Two studies reported on problems with the use of interdental brushes or floss, which sometimes caused soreness. (Six studies reported on adverse events; none…
6 studies
GRADE not reported
Not estimable. 2 studies reported adverse outcomes in terms of problems with the use of the assigned interdental cleaning aids. We were unable to pool data. (See comment) Three further studies reported that no adverse…
5 studies
GRADE not reported
Adverse effects (apart from fluorosis) · Pregnant women (for preventing dental caries in the primary teeth of their children)
1 finding from 1 review
no estimate extracted
1 study
GRADE not reported
Adverse effects · People of all ages in a previously fluoridated community (Maupome 2001: children with generally low caries experience)
The review found no eligible studies for this question.
1 finding from 1 review
Side effects · Adults, 16 years and older (dentate)
1 finding from 1 review
Adverse effects · Children and adults (with or without carious lesions)
1 finding from 1 review
Adverse effects · Children and adults (with or without carious lesions)
1 finding from 1 review
In 1 study, people complained about a transient bitter taste associated with SDF (with no associated data), with no other adverse effects. In another study, there were no adverse effects. No studies reported this…
2 studies · 336 participants
Very low
Adverse effects · Children and adults (with or without carious lesions)
1 finding from 1 review
In 1 study, 115 of 118 children had black stains on teeth treated with SDF; there were no other adverse effects or allergic reactions. In 1 study, the rate of adverse effects reported by caregiver and person who…
3 studies · 482 participants
Very low
Adverse effects · Children and adults (with or without carious lesions)
1 finding from 1 review
Ruff 2022 reported that there were no adverse events during the study period; adverse events were not defined by the study authors. Assumed data available for 1398 participants.
1 study · 1398 participants
Very low
Adverse effects · Children and adults (with or without carious lesions)
1 finding from 1 review
Adverse effects · Children and adults (with or without carious lesions)
1 finding from 1 review
Gao 2019 noted that "arrested lesions were stained black" (reported with no associated data). No other adverse effects observed, and no reports from parents of systemic disease.
1 study · 1070 participants
Very low
Adverse effects · Children and adults (with or without carious lesions)
2 findings from 1 review
1 study reported no adverse effects. 1 study reported a white discolouration of the gingiva adjacent to surfaces treated with SDF (116 surfaces) as well as redness (4 surfaces), and mild ulceration (2 surfaces). In…
2 studies · 316 participants
Very low
1 study reported 3 adverse effects in the first 48 hours. Of these, 1 effect in SDF group was possibly related to treatment (spot on corner of lip that looked like a burn), and 2 effects in placebo group were possibly…
3 studies · 983 participants
Very low
Adverse effects · Children and adults (with or without carious lesions)
1 finding from 1 review
In 1 study, black or brown staining on treated lesions was more common after SDF (OR 3.19, 95% CI 1.95 to 5.23), with no other adverse effects. 1 study reported complaints of a transient bitter taste with SDF use (with…
3 studies · 980 participants
Very low
Adverse effects · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review
Adverse effects · Children and adults (with or without carious lesions)
1 finding from 1 review
1 study (203 children) reported that black or brown staining on treated lesions was commonly found in both groups, with little or no difference according to whether SDF treatment was given in 3 applications at…
3 studies · 1121 participants
Very low
Adverse effects · Adults and adolescents with permanent posterior molar and premolar teeth suitable for Class I and II, but excluding Class V, amalgam…
The review found no eligible studies for this question.
1 finding from 1 review
Adverse effects · Children (permanent teeth; baseline 8 to 10 years)
1 finding from 1 review
Adverse effects · Children with permanent teeth (schoolchildren)
1 finding from 1 review
Adverse effects · Children (mixed dentition; baseline about 8 years)
1 finding from 1 review