What do systematic reviews say?

Colchicine (0.5 mg three times per day) vs Clofazimine (100 mg daily for 30 days, then 100 mg every other day)

• Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes

  6 months
  Clofazimine was associated with an increase in cutaneous adverse effects (Fisher's exact test P=0.015), easily controlled; there was a greater percentage of treatment interruptions in the colchicine group due to…
  1 study · 46 participants
  GRADE not reported

Colchicine (0.5 mg three times per day) vs placebo

• Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes

  6 months
  There was a greater percentage of treatment interruptions in the colchicine group due to gastrointestinal adverse effects (Fisher's exact test P=0.009). The review noted potential evidence of harm at a dose of 1.5 mg…
  1 study · 43 participants
  GRADE not reported

Colchicine (0.5 mg per day for 3 months) vs prednisolone

• Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes

  3 months
  Colchicine was associated with statistically significantly more adverse effects than prednisolone (nine participants reporting adverse effects on colchicine versus two on prednisolone).
  1 study · 34 participants
  GRADE not reported

Systemic interventions (aciclovir, thalidomide, corticosteroids, rebamipide, etanercept, colchicine, interferon-alpha) vs placebo

• Interventions for managing oral ulcers in Behçet's disease 2014 · Cochrane All outcomes
  SoF 2 (systemic interventions vs placebo), grouped comment spanning all four listed outcomes (verbatim; the review's wording "topical" is a typo for systemic): "8 placebo-controlled trials evaluated topical…
  Studies not reported
  GRADE not reported

Cyclosporin (systemic; 10 mg/kg/day for 16 weeks) vs Colchicine (systemic; 1 mg daily)

• Interventions for managing oral ulcers in Behçet's disease 2014 · Cochrane All outcomes
  Masuda 1989: multiple adverse events in the cyclosporin arm; 3 patients withdrew and 9 had a dose reduction as a result.
  1 study · 92 participants
  GRADE not reported

Intervention not reported

The intervention showed no clear difference in total adverse effects Patient reported (low certainty).

• Colchicine for pericarditis 2014 · Cochrane Headline outcomes only
  RR 1.26 [0.75, 2.12]
  4 studies · 564 participants
  Low

Intervention not reported

The intervention probably leads to higher adverse effects necessitating stop of therapy Patient reported (moderate certainty).

• Colchicine for pericarditis 2014 · Cochrane Headline outcomes only
  RR 1.87 [1.02, 3.41]
  4 studies · 564 participants
  Moderate