Findings

What do systematic reviews say?

5 questions · 5 findings · 2 reviews · Oral medicine and oral cancer

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No studies found 0 · 0%GRADE not reported 5 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Chemotherapy (any regimen; added to, or compared with, locoregional treatment) vs Locoregional treatment and/or an alternative chemotherapy regimen

Toxicity / adverse effects (harms) of chemotherapy · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer

1 finding from 1 review

Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy 2021 · Cochrane All outcomes
Harms/toxicity were planned but very little quantitative data suitable for analysis were found; toxicity reported narratively and not quantified or GRADE-rated.
Studies not reported
GRADE not reported

Antioxidants (lycopene, curcumin, Oxitard) vs Placebo or no active treatment

Adverse effects · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

1 finding from 1 review

Interventions for managing oral submucous fibrosis 2024 · Cochrane All outcomes
Adverse effects (any): 0 in placebo vs 2 minor (flatulence and bloating); 90 (1); no GRADE rating given.
1 study · 90 participants
GRADE not reported

Vasodilator vs Placebo or no active treatment

Adverse effects · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

1 finding from 1 review

Interventions for managing oral submucous fibrosis 2024 · Cochrane All outcomes
Adverse effects (any): 0 placebo vs 14 minor (transient flushing and upper trunk warmness); 85 (2); no GRADE rating.
2 studies · 85 participants
GRADE not reported

Abdominal dermal fat graft vs Nasolabial flap

Adverse effects · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

1 finding from 1 review

Interventions for managing oral submucous fibrosis 2024 · Cochrane All outcomes
Kania 2022 reported 3/30 serious adverse effects (graft failure) requiring prolonged hospital stay in the abdominal dermal fat graft group; no GRADE rating.
1 study · 30 participants
GRADE not reported

Intralesional dexamethasone injections vs placebo injection

Adverse effects · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

1 finding from 1 review

Interventions for managing oral submucous fibrosis 2024 · Cochrane All outcomes
Adverse effects (any): no adverse effects reported; 25 (1); no GRADE rating.
1 study · 25 participants
GRADE not reported