What do systematic reviews say?

Any intervention to manage relapse: fixed options (labial braces, lingual braces, fixed lingual wire) or removable options (Hawley's retainer with spring elastomeric module, Bloore removable aligner, other Hawley's retainer modifications, Invisalign, Clearstep) vs no intervention or another intervention

The review found no eligible studies for this question.

• Interventions for managing relapse of the lower front teeth after orthodontic treatment 2013 · Cochrane All outcomes
  No RCTs met the inclusion criteria for this review. After deduplication, the electronic searching identified 527 publications; after reviewing the titles and abstracts, none focused on interventions to correct the…
  0 studies
  No studies found

Any denture cleansing method (mechanical or chemical) vs Another therapy, placebo, or no treatment

The review found no eligible studies for this question.

• Interventions for cleaning dentures in adults 2009 · Cochrane All outcomes
  Noticeable absence of reports about adverse effects; no included study assessed the extent of adverse effects (for example the aftertaste of sodium hypochlorite, or mechanical or chemical damage to denture materials)…
  0 studies
  No studies found

Extraction of the primary (baby) canine (single primary tooth extraction) vs No extraction (non-intervention control)

The review found no eligible studies for this question.

• Interventions for promoting the eruption of palatally displaced permanent canine teeth, without the need for surgical… 2021 · Cochrane All outcomes
  Only root resorption was assessed; other adverse effects (gingival disease, demineralisation) were not reported.
  0 studies
  No studies found

Chemotherapy (any regimen; added to, or compared with, locoregional treatment) vs Locoregional treatment and/or an alternative chemotherapy regimen

• Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy 2021 · Cochrane All outcomes
  Harms/toxicity were planned but very little quantitative data suitable for analysis were found; toxicity reported narratively and not quantified or GRADE-rated.
  Studies not reported
  GRADE not reported

Antioxidants (lycopene, curcumin, Oxitard) vs Placebo or no active treatment

• Interventions for managing oral submucous fibrosis 2024 · Cochrane All outcomes
  Adverse effects (any): 0 in placebo vs 2 minor (flatulence and bloating); 90 (1); no GRADE rating given.
  1 study · 90 participants
  GRADE not reported

Vasodilator vs Placebo or no active treatment

• Interventions for managing oral submucous fibrosis 2024 · Cochrane All outcomes
  Adverse effects (any): 0 placebo vs 14 minor (transient flushing and upper trunk warmness); 85 (2); no GRADE rating.
  2 studies · 85 participants
  GRADE not reported

Abdominal dermal fat graft vs Nasolabial flap

• Interventions for managing oral submucous fibrosis 2024 · Cochrane All outcomes
  Kania 2022 reported 3/30 serious adverse effects (graft failure) requiring prolonged hospital stay in the abdominal dermal fat graft group; no GRADE rating.
  1 study · 30 participants
  GRADE not reported

Intralesional dexamethasone injections vs placebo injection

• Interventions for managing oral submucous fibrosis 2024 · Cochrane All outcomes
  Adverse effects (any): no adverse effects reported; 25 (1); no GRADE rating.
  1 study · 25 participants
  GRADE not reported

Double primary (canine and first molar) tooth extraction vs Single primary (canine) tooth extraction

The review found no eligible studies for this question.

• Interventions for promoting the eruption of palatally displaced permanent canine teeth, without the need for surgical… 2021 · Cochrane All outcomes
  The studies did not report adverse events.
  0 studies
  No studies found

Pedicled buccal fat pad flap (PBFPF) vs Buccal flap (BF)

• Interventions for treating oro‐antral communications and fistulae due to dental procedures 2018 · Cochrane All outcomes
  None reported as there were no treatment failures.
  1 study · 20 participants
  GRADE not reported