What do systematic reviews say?

Antidepressants vs placebo

The review found no eligible studies for this question.

• Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Acupressure at P6 point with thumb vs sham

The review found no eligible studies for this question.

• Management of gag reflex for patients undergoing dental treatment 2019 · Cochrane All outcomes
  None of the trials comparing acupressure with thumb, device or sea band to sham acupressure with or without sedation reported adverse effects.
  0 studies
  No studies found

Acupressure at P6 point with device vs sham

The review found no eligible studies for this question.

• Management of gag reflex for patients undergoing dental treatment 2019 · Cochrane All outcomes
  None of the trials comparing acupressure with thumb, device or sea band to sham acupressure with or without sedation reported adverse effects.
  0 studies
  No studies found

Antidepressant plus antipsychotic vs placebo

The review found no eligible studies for this question.

• Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Antidepressant plus antipsychotic vs placebo/no adjunctive treatment + antipsychotics

The review found no eligible studies for this question.

• Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Acupressure at P6 point with sea band vs sham

The review found no eligible studies for this question.

• Management of gag reflex for patients undergoing dental treatment 2019 · Cochrane All outcomes
  None of the trials comparing acupressure with thumb, device or sea band to sham acupressure with or without sedation reported adverse effects.
  0 studies
  No studies found

Cooling treatment (cold gel pad)+compression vs placebo (gel pad+compression)

• Local cooling for relieving pain from perineal trauma sustained during childbirth 2020 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Acupressure at P6 point with thumb plus sedation vs Sham (dummy) acupressure with sedation

The review found no eligible studies for this question.

• Management of gag reflex for patients undergoing dental treatment 2019 · Cochrane All outcomes
  None of the trials comparing acupressure with thumb, device or sea band to sham acupressure with or without sedation reported adverse effects.
  0 studies
  No studies found

Acupressure at P6 point with device plus sedation vs Sham (dummy) acupressure with sedation

The review found no eligible studies for this question.

• Management of gag reflex for patients undergoing dental treatment 2019 · Cochrane All outcomes
  None of the trials comparing acupressure with thumb, device or sea band to sham acupressure with or without sedation reported adverse effects.
  0 studies
  No studies found

Acupressure at P6 point with sea band plus sedation vs Sham (dummy) acupressure with sedation

The review found no eligible studies for this question.

• Management of gag reflex for patients undergoing dental treatment 2019 · Cochrane All outcomes
  None of the trials comparing acupressure with thumb, device or sea band to sham acupressure with or without sedation reported adverse effects.
  0 studies
  No studies found

Prednisone (oral, commencing 25 mg with phased dose reduction over 2 months) vs placebo

• Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes

  2 months
  Femiano 2003: one significant adverse event (gastritis) for the prednisone group versus none for placebo. Femiano 2010: more drug-related adverse effects for those treated with prednisone than placebo.
  2 studies
  GRADE not reported

Prednisone (oral, commencing 25 mg with phased dose reduction over 2 months) vs Montelukast (leukotriene receptor antagonist)

• Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes

  2 months
  The study reported more drug-related adverse effects for those treated with prednisone than montelukast.
  1 study · 40 participants
  GRADE not reported

Adhesively bonded amalgam restorations in conventional preparations utilising deliberate retention (all bonding agents) vs Amalgam restoration

The review found no eligible studies for this question.

• Adhesively bonded versus non‐bonded amalgam restorations for dental caries 2016 · Cochrane All outcomes
  Adverse effects: any event for which the causal relationship between the event and the amalgam restoration is at least a reasonable possibility - not measured | See comment | See comment | Not estimable | - | See…
  0 studies
  No studies found

Single preoperative dose of systemic antibiotics (clindamycin 600 mg), total chemo-mechanical debridement and root filling vs Matched placebo, total chemo-mechanical debridement and root filling

• Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults 2024 · Cochrane All outcomes

  7 days
  No adverse effects reported in the placebo group; 1 participant reported dizziness in the intervention group. 72 participants (1 study).
  1 study · 72 participants
  Low

Impregnated catheters vs non‐impregnated catheters

Impregnated catheters showed no clear difference in adverse effects (combined) Identified by clinical assessment compared with non‐impregnated catheters (high certainty).

• Catheter impregnation, coating or bonding for reducing central venous catheter‐related infections in adults 2016 · Cochrane Headline outcomes only
  RR 1.09 [0.94, 1.27]
  10 studies · 3003 participants
  High

Cyclosporin plus prednisolone vs prednisolone

• Non‐corticosteroid immunosuppressive medications for steroid‐sensitive nephrotic syndrome in children 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 87 participants
  Very low

Cyclosporin plus prednisolone vs prednisolone

It is very uncertain whether cyclosporin plus prednisolone changes adverse effects: number needing cytotoxic agents compared with prednisolone alone (very low certainty).

• Non‐corticosteroid immunosuppressive medications for steroid‐sensitive nephrotic syndrome in children 2020 · Cochrane Headline outcomes only
  RR 0.47 [0.18, 1.23]
  1 study · 104 participants
  Very low

Preoperative parenteral nutrition vs usual care or control

• Preoperative nutrition therapy in people undergoing gastrointestinal surgery 2024 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 260 participants
  GRADE not reported

Continuous positive airway pressure (CPAP) vs supportive treatment

• Continuous positive airway pressure (CPAP) for acute bronchiolitis in children 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 72 participants
  GRADE not reported

Preoperative enteral nutrition (standard formula) vs usual care or control

• Preoperative nutrition therapy in people undergoing gastrointestinal surgery 2024 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 26 participants
  GRADE not reported