What do systematic reviews say?

HP strips vs placebo

• Home‐based chemically‐induced whitening (bleaching) of teeth in adults 2018 · Cochrane All outcomes
  Mild and transient tooth sensitivity and oral irritation were the most common adverse events reported in most of the trials
  7 studies
  GRADE not reported

CP gel in tray vs HP gel in tray

• Home‐based chemically‐induced whitening (bleaching) of teeth in adults 2018 · Cochrane All outcomes
  No difference between HP and CP in tray groups in tooth sensitivity and oral irritation
  3 studies
  GRADE not reported

HP strips vs HP strips

• Home‐based chemically‐induced whitening (bleaching) of teeth in adults 2018 · Cochrane All outcomes
  Very thin gel had less tooth sensitivity than thicker gel despite higher HP; not significant
  2 studies
  GRADE not reported

SPC paint-on gel vs HP paint-on gel

• Home‐based chemically‐induced whitening (bleaching) of teeth in adults 2018 · Cochrane All outcomes
  Tooth sensitivity in one subject from both groups; one subject in 19% SPC reported oral sensitivity; all mild (Gerlach 2003)
  1 study
  GRADE not reported

STPP chewing gum vs placebo

The review found no eligible studies for this question.

• Home‐based chemically‐induced whitening (bleaching) of teeth in adults 2018 · Cochrane All outcomes
  Not reported
  Studies not reported
  No studies found

Professional oral care vs Usual oral care

• Oral care measures for preventing nursing home‐acquired pneumonia 2022 · Cochrane All outcomes
  Measured in only 1 study (834 participants), which reported no serious events and 64 non-serious events, the most common of which were oral cavity disturbances (not defined) and dental staining.
  1 study · 834 participants
  GRADE not reported

Educational intervention with information and practical components (theoretical oral health education plus practical skills training) for nursing staff and/or residents vs (Optimised) usual care

The review found no eligible studies for this question.

• Oral health educational interventions for nursing home staff and residents 2016 · Cochrane All outcomes
  None of the included studies assessed adverse effects of the intervention.
  0 studies
  No studies found

Intervention not reported

• Home‐based child development interventions for preschool children from socially disadvantaged families 2011 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Home (point‐of‐use) fortification of foods with multiple micronutrient powders vs multiple micronutrients (MMN)

• Multiple micronutrient powders for home (point‐of‐use) fortification of foods in pregnant women 2015 · Cochrane Headline outcomes only
  no estimate extracted
  0 participants
  GRADE not reported

Home (point‐of‐use) fortification of foods with multiple micronutrient powders vs iron folic acid (IFA)

• Multiple micronutrient powders for home (point‐of‐use) fortification of foods in pregnant women 2015 · Cochrane Headline outcomes only
  no estimate extracted
  0 participants
  GRADE not reported

Rubber/elastomeric cleaning stick plus toothbrushing vs Flossing plus toothbrushing

• Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlling periodontal… 2019 · Cochrane All outcomes
  Five studies assessed adverse events. One did not report findings, but the others reported either no adverse events or minor adverse events that did not significantly differ between interventions.
  5 studies
  GRADE not reported

Flossing plus toothbrushing vs Toothbrushing alone

• Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlling periodontal… 2019 · Cochrane All outcomes
  Adverse effects were assessed and reported in seven studies. Three reported no adverse events on the oral hard or soft tissues. Four reported sporadic adverse events with mild severity, with no evidence of a difference…
  7 studies
  GRADE not reported

Oral irrigation plus toothbrushing vs Toothbrushing alone

• Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlling periodontal… 2019 · Cochrane All outcomes
  Three studies reported that there were no adverse events, one reported one incidence of aphthous ulcer in irrigator group, one reported oral lacerations but found no difference between the interventions, and one did…
  5 studies
  GRADE not reported

Rubber/elastomeric cleaning stick plus toothbrushing vs Toothbrushing alone

The review found no eligible studies for this question.

• Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlling periodontal… 2019 · Cochrane All outcomes
  Harms and adverse outcomes: Not reported (neither study reported on adverse effects).
  0 studies
  No studies found

Interdental brushing plus toothbrushing vs Toothbrushing alone

• Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlling periodontal… 2019 · Cochrane All outcomes
  Harms and adverse outcomes (SoF): Neither study reported any information about adverse events. Jared 2005 assessed adverse events (participants issued a symptom diary) but did not report the findings; Graziani 2017 did…
  1 study
  GRADE not reported

Wooden cleaning stick plus toothbrushing vs Flossing plus toothbrushing

The review found no eligible studies for this question.

• Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlling periodontal… 2019 · Cochrane All outcomes
  Harms and adverse outcomes: Not reported (neither study reported on adverse effects).
  0 studies
  No studies found

Wooden cleaning stick plus toothbrushing vs Toothbrushing alone

The review found no eligible studies for this question.

• Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlling periodontal… 2019 · Cochrane All outcomes
  Harms and adverse outcomes: Not reported (neither study reported on adverse effects).
  0 studies
  No studies found

Rubber/elastomeric cleaning stick plus toothbrushing vs Interdental brushing plus toothbrushing

• Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlling periodontal… 2019 · Cochrane All outcomes
  Harms and adverse outcomes (SoF): Not reported. Yost 2006 performed examinations of the oral soft tissue at the final visit but did not report the findings; Graziani 2017 and Smith 1988 did not measure adverse effects.
  1 study
  GRADE not reported

Oral irrigation plus toothbrushing vs Flossing plus toothbrushing

• Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlling periodontal… 2019 · Cochrane All outcomes
  Both studies reported that there were no adverse events in either study group.
  2 studies
  GRADE not reported

Interdental brushing plus toothbrushing vs Flossing plus toothbrushing

• Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlling periodontal… 2019 · Cochrane All outcomes
  Five studies reported there were no adverse events. Two studies reported on problems with the use of interdental brushes or floss, which sometimes caused soreness. (Six studies reported on adverse events; none…
  6 studies
  GRADE not reported