What do systematic reviews say?

Adjunctive lithium + antipsychotics vs placebo/no adjunctive treatment + antipsychotics

It is very uncertain whether adjunctive lithium + antipsychotics changes acceptability of treatment leaving early due to any reason compared with placebo/no adjunctive treatment + antipsychotics (very low certainty).

• Lithium for schizophrenia 2015 · Cochrane Headline outcomes only
  RR 1.89 [0.93, 3.84]
  11 studies · 320 participants
  Very low

Adjunctive carbamazepine + antipsychotics vs placebo/no adjunctive treatment + antipsychotics

It is very uncertain whether adjunctive carbamazepine + antipsychotics changes acceptability of treatment Leaving the study early due to any reason compared with placebo/no adjunctive treatment + antipsychotics (very low certainty).

• Carbamazepine for schizophrenia 2014 · Cochrane Headline outcomes only
  RR 0.47 [0.16, 1.35]
  8 studies · 182 participants
  Very low

ADJUNCTIVE BENZODIAZEPINES + ANTIPSYCHOTICS vs placebo/no adjunctive treatment + antipsychotics

It is very uncertain whether ADJUNCTIVE BENZODIAZEPINES + ANTIPSYCHOTICS changes leaving the study early due to any reason (overall acceptability of… compared with PLACEBO/NO ADJUNCTIVE TREATMENT + ANTIPSYCHOTICS (very low certainty).

• Benzodiazepines for schizophrenia 2012 · Cochrane Headline outcomes only
  RR 1.36 [0.81, 2.3]
  19 studies · 1185 participants
  Very low

Lithium vs antipsychotics

It is very uncertain whether lithium changes acceptability of treatment leaving early due to any reason compared with antipsychotics (very low certainty).

• Lithium for schizophrenia 2015 · Cochrane Headline outcomes only
  RR 1.77 [1.01, 3.11]
  8 studies · 270 participants
  Very low

Perazine vs OTHER ANTIPSYCHOTICS

Perazine showed no clear difference in acceptability of treatment Leaving the studies early due to any reason compared with other antipsychotics (low certainty).

• Perazine for schizophrenia 2014 · Cochrane Headline outcomes only
  RR 0.97 [0.68, 1.38]
  6 studies · 384 participants
  Low

FLUPENTHIXOL vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS

• Flupenthixol versus low‐potency first‐generation antipsychotic drugs for schizophrenia 2014 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Benzodiazepines vs antipsychotics

It is very uncertain whether BENZODIAZEPINES changes leaving the study early due to any reason (overall acceptability of… compared with ANTIPSYCHOTICS (very low certainty).

• Benzodiazepines for schizophrenia 2012 · Cochrane Headline outcomes only
  RR 0.73 [0.45, 1.18]
  13 studies · 738 participants
  Very low