Findings

What do systematic reviews say?

10 questions · 11 findings · 3 reviews · Gynaecology and Fertility

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No studies found 1 · 9.1%GRADE not reported 0 · 0%Very low 6 · 54.5%Low 1 · 9.1%Moderate 3 · 27.3%High 0 · 0%

Summary of findings table ‐ Metformin + levonorgestrel (intrauterine system) vs levonorgestrel intrauterine system

Abnormal uterine bleeding · endometrial hyperplasia

It is very uncertain whether summary of findings table ‐ Metformin + levonorgestrel (intrauterine… changes abnormal uterine bleeding compared with levonorgestrel intrauterine system (very low certainty).

1 finding from 1 review

Metformin for endometrial hyperplasia 2024 · Cochrane Headline outcomes only
OR 0.61 [0.16, 2.27]
1 study · 49 participants
Very low

Metformin vs megestrol

Abnormal uterine bleeding · endometrial hyperplasia

It is very uncertain whether summary of findings table ‐ Metformin changes abnormal uterine bleeding compared with megestrol (very low certainty).

1 finding from 1 review

Metformin for endometrial hyperplasia 2024 · Cochrane Headline outcomes only
OR 0.91 [0.05, 15.52]
1 study · 44 participants
Very low

SPRM vs leuprolide acetate

Abnormal uterine bleeding: amenorrhoea · uterine fibroids

SPRM showed no clear difference in abnormal uterine bleeding: amenorrhoea compared with leuprolide acetate (moderate certainty).

1 finding from 1 review

Selective progesterone receptor modulators (SPRMs) for uterine fibroids 2017 · Cochrane Headline outcomes only
OR 1.14 [0.6, 2.16]
1 study · 280 participants
Moderate

SPRM vs placebo

Abnormal uterine bleeding: amenorrhoea · women with uterine fibroids

SPRM probably leads to higher abnormal uterine bleeding: amenorrhoea compared with placebo (moderate certainty).

1 finding from 1 review

Selective progesterone receptor modulators (SPRMs) for uterine fibroids 2017 · Cochrane Headline outcomes only
OR 82.5 [37.1, 183.9]
7 studies · 590 participants
Moderate

Summary of findings table ‐ Metformin + megestrol vs megestrol

Abnormal uterine bleeding ‐ not measured · endometrial hyerplasia

The review found no eligible studies for this question.

1 finding from 1 review

Metformin for endometrial hyperplasia 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

SPRM vs placebo

Abnormal uterine bleeding: change in menstrual blood loss · women with uterine fibroids

1 finding from 1 review

Selective progesterone receptor modulators (SPRMs) for uterine fibroids 2017 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 310 participants
Moderate

SPRM vs leuprolide acetate

Abnormal uterine bleeding: change in menstrual blood loss · uterine fibroids

1 finding from 1 review

Selective progesterone receptor modulators (SPRMs) for uterine fibroids 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 281 participants
Low

LNG‐IUS vs another combined low‐dose OCP

Uterine fibroid‐related symptoms (abnormal uterine bleeding, measured at 12 weeks, with the pictorial blood assessment chart (PBAC); lower = better) · women with uterine fibroids

2 findings from 1 review

Progestogens or progestogen‐releasing intrauterine systems for uterine fibroids (other than preoperative medical… 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 44 participants
Very low
Progestogens or progestogen‐releasing intrauterine systems for uterine fibroids (other than preoperative medical… 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 44 participants
Very low

Oral progestogen (dienogest, desogestrel) vs goserelin acetate

Uterine fibroid‐related symptoms (abnormal uterine bleeding, measured at 12 weeks, with the pictorial blood assessment chart (PBAC); lower = better) · women with uterine fibroids

1 finding from 1 review

Progestogens or progestogen‐releasing intrauterine systems for uterine fibroids (other than preoperative medical… 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 14 participants
Very low

LNG‐IUS vs oral progestogen (norethisterone acetate)

Change in fibroid related symptoms · women with uterine fibroids

1 finding from 1 review

Progestogens or progestogen‐releasing intrauterine systems for uterine fibroids (other than preoperative medical… 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 48 participants
Very low